Evidence map›Paper›PMID 28110436›Full record

ArticleJournal of physiology and biochemistry2017

Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.

José Antonio García, Francisco Ortiz, Javier Miana, Carolina Doerrier, Marisol Fernández-Ortiz, Iryna Rusanova, Germaine Escames, José Joaquín García, Darío Acuña-Castroviejo

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Article
  9. Article
  10. Protective Effects of Melatonin on the Skin: Future Perspectives.International journal of molecular sciences · 2019
    Review
  11. Article
  12. Article
  13. Melatonin and the electron transport chain.Cellular and molecular life sciences : CMLS · 2017
    Review
  14. Melatonin, clock genes and mitochondria in sepsis.Cellular and molecular life sciences : CMLS · 2017
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

José Antonio GarcíaCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
Francisco OrtizCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
Javier MianaDepartamento de Farmacología y Fisiología, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain.
Carolina DoerrierCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
Marisol Fernández-OrtizCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
Iryna RusanovaCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
Germaine EscamesCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
José Joaquín GarcíaDepartamento de Farmacología y Fisiología, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain.
Darío Acuña-CastroviejoCentro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Instituto de Biotecnología, Universidad de Granada, Granada, Spain. dacuna@ugr.es.ORCID http://orcid.org/0000-0002-9680-1560
Universidad de Granada · ESUniversidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NOS isoform activation is related to liver failure during sepsis, but the mechanisms driving mitochondrial impairment remain unclear. We induced sepsis by LPS administration to inducible nitric oxide synthase (iNOS

Indexed as

Disease Models, AnimalAnimalsAntioxidantsBiomarkersGene Expression Regulation, EnzymologicHepatic InsufficiencyInjections, IntraperitonealLipopolysaccharidesLiverMelatoninMice, 129 StrainMice, Inbred C57BLMice, KnockoutMitochondria, LiverNitric Oxide Synthase Type INitric Oxide Synthase Type IIAntioxidantsBiomarkersLipopolysaccharidesMelatoninNitric Oxide Synthase Type INitric Oxide Synthase Type IINos1 protein, mouseNos2 protein, mouseRNA, MessengerFree radicalsLiverLPSMelatoninMitochondriaNitric oxide synthase

Identifiers

PMID28110436
OpenAlexW2574758703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.