ArticleEnvironmental research2017
Methyl mercury, but not inorganic mercury, associated with higher blood pressure during pregnancy.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Maternal Mercury Exposure and Hypertensive Disorders of Pregnancy: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Pooled it
- Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose-response Meta-analysis.Environmental health perspectives · 2018Pooled it
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- Article
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- Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.Environmental health perspectives · 2023Article
- Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers.Biological trace element research · 2022Article
- Cardiometabolic risk factors and mercury content in hair of women from a territory distant from mercury-rich geochemical zones (Cherepovets city, Northwest Russia).Environmental geochemistry and health · 2021Article
- Oral methylmercury intoxication aggravates cardiovascular risk factors and accelerates atherosclerosis lesion development in ApoE knockout and C57BL/6 mice.Toxicological research · 2021Article
- Seafood, wine, rice, vegetables, and other food items associated with mercury biomarkers among seafood and non-seafood consumers: NHANES 2011-2012.Journal of exposure science & environmental epidemiology · 2020Article
- Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health.Reproductive toxicology (Elmsford, N.Y.) · 2020Review
- A Green, Rapid and Efficient Dual-Sensors for Highly Selective and Sensitive Detection of Cation (HgPolymers · 2020Article
- Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay.Biochimica et biophysica acta. General subjects · 2019Review
- High Efficiency Mercury Sorption by Dead Biomass ofMaterials (Basel, Switzerland) · 2019Article
- Co-exposure to environmental endocrine disruptors in the US population.Environmental science and pollution research international · 2019Article
- Blood total mercury and methylmercury among pregnant mothers in Charleston, South Carolina, USA.Journal of exposure science & environmental epidemiology · 2018Article
- Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study.The international journal of occupational and environmental medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 1 country.
Funding
Abstract
Prior studies addressing associations between mercury and blood pressure have produced inconsistent findings; some of this may result from measuring total instead of speciated mercury. This cross-sectional study of 263 pregnant women assessed total mercury, speciated mercury, selenium, and n-3 polyunsaturated fatty acids in umbilical cord blood and blood pressure during labor and delivery. Models with a) total mercury or b) methyl and inorganic mercury were evaluated. Regression models adjusted for maternal age, race/ethnicity, prepregnancy body mass index, neighborhood income, parity, smoking, n-3 fatty acids and selenium. Geometric mean total, methyl, and inorganic mercury concentrations were 1.40µg/L (95% confidence interval: 1.29, 1.52); 0.95µg/L (0.84, 1.07); and 0.13µg/L (0.10, 0.17), respectively. Elevated systolic BP, diastolic BP, and pulse pressure were found, respectively, in 11.4%, 6.8%, and 19.8% of mothers. In adjusted multivariable models, a one-tertile increase of methyl mercury was associated with 2.83mmHg (0.17, 5.50) higher systolic blood pressure and 2.99mmHg (0.91, 5.08) higher pulse pressure. In the same models, an increase of one tertile of inorganic mercury was associated with -1.18mmHg (-3.72, 1.35) lower systolic blood pressure and -2.51mmHg (-4.49, -0.53) lower pulse pressure. No associations were observed with diastolic pressure. There was a non-significant trend of higher total mercury with higher systolic blood pressure. We observed a significant association of higher methyl mercury with higher systolic and pulse pressure, yet higher inorganic mercury was significantly associated with lower pulse pressure. These results should be confirmed with larger, longitudinal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.