Trial reportJournal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology2017
Dopaminergic modulation of multi-muscle synergies in postural tasks performed by patients with Parkinson's disease.
Trial report in Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A methodological scoping review on EMG processing and synergy-based results in muscle synergy studies in Parkinson's disease.Frontiers in bioengineering and biotechnology · 2024Pooled it
- Body Posture, Postural Stability, and Metabolic Age in Patients with Parkinson's Disease.BioMed research international · 2017Trial
- Two-digit grasp as pointing movements by the opposing digits: evidence based on the uncontrolled manifold analysis.Experimental brain research · 2026Article
- Levodopa-induced alterations in vertical center of mass and muscle synergy structure during Parkinsonian gait.Experimental brain research · 2026Article
- Functional changes in spinal circuitry in essential tremor revealed with analysis of intramuscle synergies.Journal of neurophysiology · 2026Article
- Stability of performance in a hierarchical system during isometric force production and effects of visual feedback.Experimental brain research · 2025Article
- Reaching and stepping respond differently to medication and cueing in Parkinson's disease.Scientific reports · 2024Article
- Two aspects of feed-forward control of action stability: effects of action speed and unexpected events.Experimental brain research · 2024Article
- Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions.International journal of molecular sciences · 2023Article
- Muscle synergies in Parkinson's disease before and after the deep brain stimulation of the bilateral subthalamic nucleus.Scientific reports · 2023Article
- Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing.Neurotoxicology · 2022Article
- Recent Advances in the Neural Control of Movements: Lessons for Functional Recovery.Physical therapy research · 2022Review
- One more time about motor (and non-motor) synergies.Experimental brain research · 2021Review
- An Algorithm for Choosing the Optimal Number of Muscle Synergies during Walking.Sensors (Basel, Switzerland) · 2021Article
- Stability of Action and Kinesthetic Perception in Parkinson's Disease.Journal of human kinetics · 2021Article
- Synergic control of action in levodopa-naïve Parkinson's disease patients: II. Multi-muscle synergies stabilizing vertical posture.Experimental brain research · 2020Article
- Fifteen Years of Wireless Sensors for Balance Assessment in Neurological Disorders.Sensors (Basel, Switzerland) · 2020Review
- Muscle Synergies in Parkinson's Disease.Sensors (Basel, Switzerland) · 2020Review
- Postural Behavior in Medicated Parkinson Disease Patients: A Preliminary Study Searching for Indicators to Track Progress.Journal of central nervous system disease · 2020Article
- Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease.Biomolecules · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPostural instability is one of most disabling motor symptoms in Parkinson's disease. Indices of multi-muscle synergies are new measurements of postural stability.
objectivesWe explored the effects of dopamine-replacement drugs on multi-muscle synergies stabilizing center of pressure coordinate and their adjustments prior to a self-triggered perturbation in patients with Parkinson's disease. We hypothesized that both synergy indices and synergy adjustments would be improved on dopaminergic drugs.
methodsPatients at Hoehn-Yahr stages II and III performed whole-body tasks both off- and on-drugs while standing. Muscle modes were identified as factors in the muscle activation space. Synergy indices stabilizing center of pressure in the anterior-posterior direction were quantified in the muscle mode space during a load-release task.
resultsDopamine-replacement drugs led to more consistent organization of muscles in stable groups (muscle modes). On-drugs patients showed larger indices of synergies and anticipatory synergy adjustments. In contrast, no medication effects were seen on anticipatory postural adjustments or other performance indices.
conclusionsDopamine-replacement drugs lead to significant changes in characteristics of multi-muscle synergies in Parkinson's disease. Studies of synergies may provide a biomarker sensitive to problems with postural stability and agility and to efficacy of dopamine-replacement therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.