ArticleBone2017
Assessment of collagen quality associated with non-enzymatic cross-links in human bone using Fourier-transform infrared imaging.
Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- A Clinical Perspective on Advanced Developments in Bone Biopsy Assessment in Rare Bone Disorders.Frontiers in endocrinology · 2020Pooled it
- Multiscale mechano-biological characterization of necrotic, sclerotic, and healthy zones in femoral head osteonecrosis: linking viscoelastic heterogeneity to mechanical failure.Calcified tissue international · 2026Article
- The sex-specific effects of RAGE signaling and type 2 diabetes on mouse cortical bone mechanics, structure, and material properties.Mechanobiology in medicine · 2025Article
- Article
- Article
- From Structure to Strength: Analyzing the Impact of Sulfuric Acid on Pig Bone Demineralization Through FTIR, LIBS, and AAS.International journal of molecular sciences · 2024Article
- Review
- Article
- Hybrid Hydroxyapatite-Metal Complex Materials Derived from Amino Acids and Nucleobases.Molecules (Basel, Switzerland) · 2024Review
- Machine learning-assisted mid-infrared spectrochemical fibrillar collagen imaging in clinical tissues.Journal of biomedical optics · 2024Article
- Review
- Machine learning assisted mid-infrared spectrochemical fibrillar collagen imaging in clinical tissues.bioRxiv : the preprint server for biology · 2024Article
- Aging impairs the osteocytic regulation of collagen integrity and bone quality.Bone research · 2024Article
- Assessment of bovine cortical bone fracture behavior using impact microindentation as a surrogate of fracture toughness.JBMR plus · 2024Article
- A fresh perspective on infrared spectroscopy as a prescreening method for molecular and stable isotopes analyses on ancient human bones.Scientific reports · 2024Article
- Review
- Validation of Fourier Transform Infrared Microspectroscopy for the Evaluation of Enzymatic Cross-Linking of Bone Collagen.Calcified tissue international · 2023Article
- Type 2 diabetes alters the viscoelastic behavior and macromolecular composition of vertebra.Bone reports · 2023Article
- Article
- Preventing Disused Bone Loss through Inhibition of Advanced Glycation End Products.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Aging and many disease conditions, most notably diabetes, are associated with the accumulation of non-enzymatic cross-links in the bone matrix. The non-enzymatic cross-links, also known as advanced glycation end products (AGEs), occur at the collagen tissue level, where they are associated with reduced plasticity and increased fracture risk. In this study, Fourier-transform infrared (FTIR) imaging was used to detect spectroscopic changes associated with the formation of non-enzymatic cross-links in human bone collagen. Here, the non-enzymatic cross-link profile was investigated in one cohort with an in vitro ribose treatment as well as another cohort with an in vivo bisphosphonate treatment. With FTIR imaging, the two-dimensional (2D) spatial distribution of collagen quality associated with non-enzymatic cross-links was measured through the area ratio of the 1678/1692cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.