ArticleSchizophrenia research2017
Diminished auditory sensory gating during active auditory verbal hallucinations.
Article in Schizophrenia research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Corollary discharge dysfunction in auditory verbal hallucinations: N100 suppression measured with semi-dry electrodes.Clinical neurophysiology practice · 2026Article
- Cognitive-Developmental Mechanisms in Hallucinations.Schizophrenia bulletin · 2025Review
- N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia.Schizophrenia bulletin · 2025Article
- Common and unique white matter fractional anisotropy patterns in patients with schizophrenia with medication-resistant auditory verbal hallucinations: a retrospective tract-based spatial statistics study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Biomarkers of Auditory-Verbal Hallucinations.Advances in neurobiology · 2024Review
- Article
- N-methyl-D-aspartate receptor antagonism impairs sensory gating in the auditory cortex in response to speech stimuli.Psychopharmacology · 2022Article
- Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders.Brain sciences · 2021Article
- Aberrant inhibitory processing in the somatosensory cortices of cannabis-users.Journal of psychopharmacology (Oxford, England) · 2021Article
- Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults.Aging · 2021Article
- The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels.Frontiers in neuroscience · 2021Review
- Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia: An ERP Study.Frontiers in psychiatry · 2021Article
- Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study.Frontiers in psychiatry · 2021Article
- Methodological considerations for a better somatosensory gating paradigm: The impact of the inter-stimulus interval.NeuroImage · 2020Article
- Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Is schizotypic maternal personality linked to sensory gating abilities during infancy?Experimental brain research · 2019Article
- Rhythmic Spontaneous Activity Mediates the Age-Related Decline in Somatosensory Function.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging.Progress in molecular biology and translational science · 2019Review
- Auditory Verbal Hallucinations in Schizophrenia From a Levels of Explanation Perspective.Schizophrenia bulletin · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Auditory sensory gating, assessed in a paired-click paradigm, indicates the extent to which incoming stimuli are filtered, or "gated", in auditory cortex. Gating is typically computed as the ratio of the peak amplitude of the event related potential (ERP) to a second click (S2) divided by the peak amplitude of the ERP to a first click (S1). Higher gating ratios are purportedly indicative of incomplete suppression of S2 and considered to represent sensory processing dysfunction. In schizophrenia, hallucination severity is positively correlated with gating ratios, and it was hypothesized that a failure of sensory control processes early in auditory sensation (gating) may represent a larger system failure within the auditory data stream; resulting in auditory verbal hallucinations (AVH). EEG data were collected while patients (N=12) with treatment-resistant AVH pressed a button to indicate the beginning (AVH-on) and end (AVH-off) of each AVH during a paired click protocol. For each participant, separate gating ratios were computed for the P50, N100, and P200 components for each of the AVH-off and AVH-on states. AVH trait severity was assessed using the Psychotic Symptoms Rating Scales AVH Total score (PSYRATS). The results of a mixed model ANOVA revealed an overall effect for AVH state, such that gating ratios were significantly higher during the AVH-on state than during AVH-off for all three components. PSYRATS score was significantly and negatively correlated with N100 gating ratio only in the AVH-off state. These findings link onset of AVH with a failure of an empirically-defined auditory inhibition system, auditory sensory gating, and pave the way for a sensory gating model of AVH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.