Evidence map›Paper›PMID 28109471›Full record

ArticleOral oncology2017

Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma.

Aswini R Krishnan, Avinaash Korrapati, Angela E Zou, Yuanhao Qu, Xiao Qi Wang, Joseph A Califano, Jessica Wang-Rodriguez, Scott M Lippman, Melbourne F Hovell, Weg M Ongkeko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. The Biogenesis and Functions of piRNAs in Human Diseases.Molecular therapy. Nucleic acids · 2020
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. piRDisease v1.0: a manually curated database for piRNA associated diseases.Database : the journal of biological databases and curation · 2019
    Article
  13. Article
  14. A Looking-Glass of Non-coding RNAs in oral cancer.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Aswini R KrishnanDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, CA, United States. Electronic address: arkrishn@ucsd.edu.
Avinaash KorrapatiDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, CA, United States. Electronic address: akorrapa@ucsd.edu.
Angela E ZouDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, CA, United States. Electronic address: azou@ucsd.edu.
Yuanhao QuDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, CA, United States. Electronic address: yuq024@ucsd.edu.
Xiao Qi WangDepartment of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China. Electronic address: xqwang@hku.hk.
Joseph A CalifanoDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, CA, United States. Electronic address: jcalifano@ucsd.edu.
Jessica Wang-RodriguezVeterans Administration Medical Center and Department of Pathology, University of California, San Diego, La Jolla, CA, United States. Electronic address: jessica.wang-rodriguez@va.gov.
Scott M LippmanDepartment of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, CA, United States. Electronic address: slippman@ucsd.edu.
Melbourne F HovellGraduate School of Public Health, San Diego State University, San Diego, CA, United States. Electronic address: mhovell@cbeachsdsu.org.
Weg M OngkekoDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, CA, United States. Electronic address: wongkeko@ucsd.edu.
University of California, San Diego · USSan Diego State University · USUniversity of Hong Kong · HK

Funding

Non-coding RNAs in salivary gland tumorR21DE023242 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ONGKEKO, RUTHERFORD M · 2012 to 2013
$417k
NIDCR NIH HHS R21 DE023242
6 · The paper itself

Abstract

objectiveSmoking remains a primary etiological factor in head and neck squamous cell carcinoma (HNSCC). Given that non-coding RNAs (ncRNAs), including PIWI-interacting RNAs (piRNAs), have emerged as mediators of initiation and progression in head and neck malignancies, we undertook a global study of piRNA expression patterns in smoking-associated HNSCC. MATERIALS AND

methodsUsing RNA-sequencing data from 256 current smoker and lifelong nonsmoker samples in The Cancer Genome Atlas (TCGA), we analyzed the differential expression patterns of 27,127 piRNAs across patient cohorts stratified by tobacco use, with HPV16 status and tumor status taken into account. We correlated their expression to clinical characteristics and to smoking-induced alterations of PIWI proteins, the functional counterparts of piRNAs. Finally, we correlated our identified piRNAs and PIWI proteins to known chromosomal aberrations in HNSCC to understand their wider-ranging genomic effects. RESULTS AND

conclusionOur analyses implicated a 13-member piRNA panel in smoking-related HNSCC, among which NONHSAT123636 and NONHSAT113708 associated with tumor stage, NONHSAT067200 with patient survival, and NONHSAT081250 with smoking-altered PIWIL1 protein expression. 6 piRNAs as well as PIWIL1 correlated with genomic alterations common to HNSCC, including TP53 mutation, TP53-3p co-occurrence, and 3q26, 8q24, and 11q13 amplification. Collectively, our findings provide novel insights into the etiology-specific piRNA landscape of smoking-induced HNSCC.

Indexed as

SmokingCarcinoma, Squamous CellFemaleHead and Neck NeoplasmsHumansMaleRNA, Small InterferingSquamous Cell Carcinoma of Head and NeckRNA, Small InterferingHead and neck neoplasmsRNASmall interferingSmoking

Identifiers

PMID28109471
PMCPMC5291169
OpenAlexW2563376882

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.