ArticleJournal of veterinary internal medicine2017
Changes in Serum Creatinine Concentration and Acute Kidney Injury (AKI) Grade in Dogs Treated with Hydroxyethyl Starch 130/0.4 From 2013 to 2015.
Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Perioperative management of septic peritonitis in small animals: A review.Veterinary surgery : VS · 2026Review
- Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs.Scientific reports · 2023Article
- Stage 1-Biomarkers of Kidney Injury in Dogs Undergoing Constant Rate Infusion of Hydroxyethyl Starch 130/0.4.Animals : an open access journal from MDPI · 2021Article
- Colloids Yes or No? - a "Gretchen Question" Answered.Frontiers in veterinary science · 2021Review
- Fluid Therapy in Dogs and Cats With Sepsis.Frontiers in veterinary science · 2021Review
- Current Concepts in Fluid Therapy in Horses.Frontiers in veterinary science · 2021Review
- Effects of IV Fluids in Dogs and Cats With Kidney Failure.Frontiers in veterinary science · 2021Review
- Assessment of Hydroxyethyl Starch (6% HES 130/0.4) Kidney Storage in Critically Ill Dogs: A Post-mortem Prospective Study.Frontiers in veterinary science · 2021Article
- Which risk predictors are more likely to indicate severe AKI in hospitalized patients?International journal of medical informatics · 2020Article
- Blood acid-base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs.Journal of the South African Veterinary Association · 2020Article
- Membrane-based therapeutic plasma exchange in dogs: Prescription, anticoagulation, and metabolic response.Journal of veterinary internal medicine · 2019Article
- Fractional excretion of electrolytes in volume-responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications.Journal of veterinary internal medicine · 2018Observational
- Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs.Journal of veterinary internal medicine · 2018Article
- Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union.Frontiers in veterinary science · 2018Review
- Effects of Hydroxyethyl Starch 130/0.4 on Serum Creatinine Concentration and Development of Acute Kidney Injury in Nonazotemic Cats.Journal of veterinary internal medicine · 2017Article
- Current Trends in Volume Replacement Therapy and the Use of Synthetic Colloids in Small Animals-An Internet-Based Survey (2016).Frontiers in veterinary science · 2017Article
- Treatment of Naproxen Overdose Using Therapeutic Plasma Exchange and Plasmaperfusion in a Dog.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHydroxyethyl starch (HES) solutions may cause acute kidney injury (AKI) in humans.
objectiveTo compare AKI grades in 94 dogs exposed and 90 dogs that were unexposed to 6% HES-130/0.4. ANIMALS: Dogs receiving 6% HES-130/0.4 (HES cohort) or crystalloids (unexposed cohort) between 2013 and 2015.
methodsHistorical cohort study. Diagnosis, total cumulative dose and total mL/kg of HES administered, time frame of HES administration and serum creatinine concentrations up to 90 days after initiation of HES treatment were retrospectively reviewed. The AKI grades were retrospectively determined by IRIS guidelines.
resultsExposed dogs received a median cumulative dose of 69.4 mL/kg (range, 2-429 mL/kg) HES over a median of 4 (range, 1-16) days, resulting in a median dose of 20.7 (range, 2-87) mL/kg/d. Although the cohorts differed in terms of age and diagnosis, AKI grades were not significantly different at the evaluated short- and long-term time points. Results of ordinal logistic regression identified the number of days of HES administration as significantly associated with an increase in AKI grade within 10 days (P = .038), whereas there was no significant association among HES exposure, HES mL/kg/d, and an increase in AKI grade. CONCLUSIONS AND CLINICAL IMPORTANCE: HES-130/0.4-treated dogs were not more prone to develop AKI than HES-untreated, but the number of HES days was significantly associated with an increase in AKI grade within 10 days post-HES administration. The time frame of HES treatment should be kept short. Prospective, randomized clinical trials are required to assess the effect of HES on renal function in dogs.
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