Evidence map›Paper›PMID 28109071›Full record

ReviewCPT: pharmacometrics & systems pharmacology2017

Implementing Genomic Clinical Decision Support for Drug-Based Precision Medicine.

R R Freimuth, C M Formea, J M Hoffman, E Matey, J F Peterson, R D Boyce

Abstract readEditorialReview
In one paragraph

Review in CPT: pharmacometrics & systems pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2YClinical pharmacology and therapeutics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.Annual review of genomics and human genetics · 2022
    Review
  12. Approaches to assessing the provider experience with clinical pharmacogenomic information: a scoping review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. User stories as lightweight requirements for agile clinical decision support development.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
  18. Essential Characteristics of Pharmacogenomics Study Publications.Clinical pharmacology and therapeutics · 2019
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R R FreimuthDepartment of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.
C M FormeaDepartment of Pharmacy, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.
J M HoffmanDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
E MateyDepartment of Pharmacy, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.
J F PetersonDepartment of Biomedical Informatics and Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
R D BoyceDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Integrated, Individualized, Intelligent Prescribing (I3P)U01HG007253 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVY, MIA A., PETERSON, JOSEPH F. · 2014 to 2018
$4.6M
Clinical Pharmacogenetics Implementation Consortium (CPIC)R24GM115264 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KLEIN, TERI ELLEN, RELLING, MARY V · 2015 to 2017
$3.6M
Addressing gaps in clinically useful evidence on drug-drug interactionsR01LM011838 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYCE, RICHARD DAVID · 2014 to 2017
$1.6M
NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG007253NIGMS NIH HHS R24 GM115264NLM NIH HHS R01 LM011838
6 · The paper itself

Abstract

The explosive growth of patient-specific genomic information relevant to drug therapy will continue to be a defining characteristic of biomedical research. To implement drug-based personalized medicine (PM) for patients, clinicians need actionable information incorporated into electronic health records (EHRs). New clinical decision support (CDS) methods and informatics infrastructure are required in order to comprehensively integrate, interpret, deliver, and apply the full range of genomic data for each patient.

Indexed as

Decision Support Systems, ClinicalElectronic Health RecordsDatabases, GeneticGenomicsHumansPrecision Medicine

Identifiers

PMID28109071
PMCPMC5351408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.