ArticlePlant molecular biology2017
Heme oxygenase 1 defects lead to reduced chlorophyll in Brassica napus.
Article in Plant molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 57 citations in OpenAlex.
- Biochemical and Transcriptome Analysis Reveals Pigment Biosynthesis Influenced Chlorina Leaf Formation in Anoectochilus roxburghii (Wall.) Lindl.Biochemical genetics · 2024Article
- Metabolic Adaptations in Rapeseed: Hemin-Induced Resilience to NaCl Stress by Enhancing Growth, Photosynthesis, and Cellular Defense Ability.Metabolites · 2024Article
- Photosynthetic characteristics and genetic mapping of a new yellow leaf mutantMolecular breeding : new strategies in plant improvement · 2023Article
- Mechanisms for leaf color changes in Osmanthus fragrans 'Ziyan Gongzhu' using physiology, transcriptomics and metabolomics.BMC plant biology · 2023Article
- Exogenous Hemin alleviates NaCl stress by promoting photosynthesis and carbon metabolism in rice seedlings.Scientific reports · 2023Article
- Article
- Fine Mapping and Characterization of a Major Gene Responsible for Chlorophyll Biosynthesis inBiomolecules · 2022Article
- Bulk segregant analysis-sequencing and RNA-Seq analyses reveal candidate genes associated with albino phenotype inFrontiers in plant science · 2022Article
- Exploring the gene pool of Brassica napus by genomics-based approaches.Plant biotechnology journal · 2021Review
- A mutation in CsHY2 encoding a phytochromobilin (PΦB) synthase leads to an elongated hypocotyl 1(elh1) phenotype in cucumber (Cucumis sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Characterization and transcriptomic analysis of a novel yellow-green leaf wucai (Brassica campestris L.) germplasm.BMC genomics · 2021Article
- Exogenous hemin improves CdScientific reports · 2021Article
- Characterization and Fine Mapping of a Yellow-Virescent Gene Regulating Chlorophyll Biosynthesis and Early Stage Chloroplast Development inG3 (Bethesda, Md.) · 2020Article
- Disruption of carotene biosynthesis leads to abnormal plastids and variegated leaves in Brassica napus.Molecular genetics and genomics : MGG · 2020Article
- Comparative transcriptome and metabolite profiling of four tissues from Alisma orientale (Sam.) Juzep reveals its inflorescence developmental and medicinal characteristics.Scientific reports · 2019Article
- Physiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves.PloS one · 2019Article
- Transcriptome profiling reveals the roles of pigment mechanisms in postharvest broccoli yellowing.Horticulture research · 2019Article
- Article
- Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.Oxidative medicine and cellular longevity · 2018Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously described a Brassica napus chlorophyll-deficient mutant (ygl) with yellow-green seedling leaves and mapped the related gene, BnaC.YGL, to a 0.35 cM region. However, the molecular mechanisms involved in this chlorophyll defect are still unknown. In this study, the BnaC07.HO1 gene (equivalent to BnaC.YGL) was isolated by the candidate gene approach, and its function was confirmed by genetic complementation. Comparative sequencing analysis suggested that BnaC07.HO1 was lost in the mutant, while a long noncoding-RNA was inserted into the promoter of the homologous gene BnaA07.HO1. This insert was widely present in B. napus cultivars and down-regulated BnaA07.HO1 expression. BnaC07.HO1 was highly expressed in the seedling leaves and encoded heme oxygenase 1, which was localized in the chloroplast. Biochemical analysis showed that BnaC07.HO1 can catalyze heme conversion to form biliverdin IXα. RNA-seq analysis revealed that the loss of BnaC07.HO1 impaired tetrapyrrole metabolism, especially chlorophyll biosynthesis. According, the levels of chlorophyll intermediates were reduced in the ygl mutant. In addition, gene expression in multiple pathways was affected in ygl. These findings provide molecular evidences for the basis of the yellow-green leaf phenotype and further insights into the crucial role of HO1 in B. napus.
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