ReviewProtein & cell2017
Physiological links of circadian clock and biological clock of aging.
Review in Protein & cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- The Synaptic Clock: SynGAP1 as a Molecular Timer of Postsynaptic Density Consolidation.Biomolecules · 2026Review
- Are we trapped on Earth: space and accelerated ageing.NPJ microgravity · 2025Review
- Exploring the biological mechanisms of obesity affecting breast cancer from a multidimensional perspective.Discover oncology · 2025Review
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- Modeling the geometry of circadian synchronization and period across aging.Biogerontology · 2025Article
- Role of circadian rhythms in heart failure: insights from myocardial energy metabolism.Journal of translational medicine · 2025Review
- Association of marital status with DNA methylation-based biological age among US older adults.Frontiers in public health · 2025Article
- Article
- Sleep Duration and Functional Disability Among Chinese Older Adults: Cross-Sectional Study.JMIR aging · 2024Article
- High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.iScience · 2024Article
- Understanding Circadian and Circannual Behavioral Cycles of Captive Giant Pandas (Animals : an open access journal from MDPI · 2023Article
- The circadian clock and extracellular matrix homeostasis in aging and age-related diseases.American journal of physiology. Cell physiology · 2023Review
- Blue light exposure-dependent improvement in robustness of circadian rest-activity rhythm in aged rats.PloS one · 2023Article
- Latest advances in the study of non-coding RNA-mediated circadian rhythm disorders causing endometrial cancer.Frontiers in oncology · 2023Review
- Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders.Frontiers in molecular neuroscience · 2023Article
- Article
- The circadian transcription factor ARNTL2 is regulated by weight-loss interventions in human white adipose tissue and inhibits adipogenesis.Cell death discovery · 2022Article
- ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude.Communications biology · 2022Article
- Four novel genes associated with longevity found in Cane corso purebred dogs.BMC veterinary research · 2022Article
- Genes and Longevity of Lifespan.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms orchestrate biochemical and physiological processes in living organisms to respond the day/night cycle. In mammals, nearly all cells hold self-sustained circadian clocks meanwhile couple the intrinsic rhythms to systemic changes in a hierarchical manner. The suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master pacemaker to initiate daily synchronization according to the photoperiod, in turn determines the phase of peripheral cellular clocks through a variety of signaling relays, including endocrine rhythms and metabolic cycles. With aging, circadian desynchrony occurs at the expense of peripheral metabolic pathologies and central neurodegenerative disorders with sleep symptoms, and genetic ablation of circadian genes in model organisms resembled the aging-related features. Notably, a number of studies have linked longevity nutrient sensing pathways in modulating circadian clocks. Therapeutic strategies that bridge the nutrient sensing pathways and circadian clock might be rational designs to defy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.