ArticleInternational journal of bipolar disorders2017
The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies.
Article in International journal of bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Review
- Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction.BMC psychiatry · 2019Article
- The Link between Thyroid Autoimmunity, Depression and Bipolar Disorder.Open medicine (Warsaw, Poland) · 2019Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
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Abstract
backgroundPrevious studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence's and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a mood disorder) compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor (trait marker) for BD development.
objectivesHere we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a 'trait' marker for BD. The present study aims to investigate whether TPO-Abs (1) are stable over time, (2) are associated with lithium-exposure, (3) share a common genetic background with BD and are related to psychopathology.
resultsIn bipolar offspring and twins, the prevalence of TPO-Abs is stable over time (r
conclusionsAlthough our results show a trend toward an increased inherited risk of the co-occurrence of BD and thyroid autoimmunity, large-scale studies can only draw final conclusions. Nationwide epidemiological and GWAS studies reach such numbers and support the view of a possible common (autoimmune) etiology of severe mood disorders and chronic recurrent infections and autoimmunity, including thyroid autoimmunity.
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