Evidence map›Paper›PMID 28108907›Full record

ArticleInternational ophthalmology2018

Peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in adult-onset familial Mediterranean fever.

Sait Alim, Mehmet Esen, Ayşe Kevser Demir, Selim Demir, Hüseyin Ortak, Alper Güneş, Tufan Alatli, Helin Deniz Demir

Abstract read
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In one paragraph

Article in International ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sait AlimDepartment of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. drsaitalim@gmail.com.ORCID http://orcid.org/0000-0003-1237-4264
Mehmet EsenDepartment of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Ayşe Kevser DemirDepartment of Internal Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Selim DemirDepartment of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Hüseyin OrtakDepartment of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Alper GüneşDepartment of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Tufan AlatliDepartment of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Helin Deniz DemirDepartment of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Tokat Gaziosmanpaşa Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF).

methodsForty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography. The patients were divided into two groups according to their disease severity score, M694V gene mutation, colchicine dosage used per day, colchicine usage time period and number of FMF attacks per year.

resultsThere were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness in patients with adult-onset FMF and controls.

conclusionAccording to our study, it looks like that neither adult-onset FMF nor colchicine has any effect on the RNFL and GCIPL thicknesses. Further studies with a large sample size are needed.

Indexed as

AdultChromosomes, Human, Pair 16ColchicineDNADNA Mutational AnalysisDose-Response Relationship, DrugFamilial Mediterranean FeverFemaleHumansMaleMutationNerve FibersOptic DiskPyrinRetinal Ganglion CellsSeverity of Illness IndexColchicineDNAMEFV protein, humanPyrinTubulin ModulatorsColchicineDisease severity scoreGanglion cell–inner plexiform layer thicknessM694V gene mutationOptical coherence tomographyRetinal nerve fiber layer thickness

Identifiers

PMID28108907
OpenAlexW2573187119

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.