Evidence map›Paper›PMID 28108877›Full record

ArticleAIDS and behavior2017

A Moderated Mediation Model of HIV-Related Stigma, Depression, and Social Support on Health-Related Quality of Life among Incarcerated Malaysian Men with HIV and Opioid Dependence.

Roman Shrestha, Michael Copenhaver, Alexander R Bazazi, Tania B Huedo-Medina, Archana Krishnan, Frederick L Altice

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Psychometric Properties of the Berger HIV Stigma Scale: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  2. Article
  3. Health-related quality of life measures in incarcerated populations: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Factors associated with quality of life, depressive symptoms, and perceived stress among rural older adults living with HIV in the United States.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2023
    Article
  11. Article
  12. Observational
  13. Perceived Supportive Paradox After Diagnosing Human Papillomavirus: A Qualitative Content Analysis.International journal of community based nursing and midwifery · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Understanding Global HIV Stigma and Discrimination: Are Contextual Factors Sufficiently Studied? (GAPInternational journal of environmental research and public health · 2019
    Article
  19. Geriatric-HIV Medicine: the geriatrician's role.European geriatric medicine · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Roman ShresthaDepartment of Community Medicine & Health Care, University of Connecticut Health Center, 263 Farmington Avenue, MC 6325, Farmington, CT, 06030-6325, USA. Roman.Shrestha@UConn.edu.ORCID http://orcid.org/0000-0003-4340-3101
Michael CopenhaverInstitute for Collaboration on Health, Intervention and Policy, University of Connecticut, Storrs, CT, USA.
Alexander R BazaziDepartment of Internal Medicine, Section of Infectious Diseases, AIDS Program, Yale University School of Medicine, New Haven, CT, USA.
Tania B Huedo-MedinaInstitute for Collaboration on Health, Intervention and Policy, University of Connecticut, Storrs, CT, USA.
Archana KrishnanInstitute for Collaboration on Health, Intervention and Policy, University of Connecticut, Storrs, CT, USA.
Frederick L AlticeInstitute for Collaboration on Health, Intervention and Policy, University of Connecticut, Storrs, CT, USA.
University of Connecticut · USAlbany State University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice SettingsR01DA041271 · NIDA · YALE UNIVERSITY · PI SHENOI, SHEELA · 2016 to 2021
$3.3M
Intervention of HIV, Drug Use and the Criminal Justice System in MalaysiaR01DA025943 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2008 to 2012
$2.7M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
HIV Prevention and Adherence Among Priority Drug Using PopulationsK02DA033139 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI COPENHAVER, MICHAEL · 2013 to 2017
$697k
Improving HIV and substance use disorder treatment research by integrating randomized and nonrandomized studies: an evaluation of methadone for HIV-infected opioid-dependent Malaysian prisoners.F30DA039716 · NIDA · YALE UNIVERSITY · PI BAZAZI, ALEXANDER REZA · 2015 to 2017
$123k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS F30 DA039716NIDA NIH HHS K02 DA033139NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA025943NIDA NIH HHS R01 DA041271NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Although it is well established that HIV-related stigma, depression, and lack of social support are negatively associated with health-related quality of life (HRQoL) among people living with HIV (PLH), no studies to date have examined how these psychosocial factors interact with each other and affect HRQoL among incarcerated PLH. We, therefore, incorporated a moderated mediation model (MMM) to explore whether depression mediates the effect of HIV-related stigma on HRQoL as a function of the underlying level of social support. Incarcerated HIV-infected men with opioid dependence (N = 301) were recruited from the HIV units in Kajang prison in Malaysia. Participants completed surveys assessing demographic characteristics, HIV-related stigma, depression, social support, and HRQoL. Results showed that the effect of HIV-related stigma on HRQoL was mediated via depression (a1:β = 0.1463, p < 0.001; b1:β = -0.8392, p < 0.001), as demonstrated by the two-tailed significance test (Sobel z = -3.8762, p < 0.001). Furthermore, the association between social support and HRQoL was positive (β = 0.4352, p = 0.0433), whereas the interaction between HIV-related stigma and depression was negatively associated with HRQOL (β = -0.0317, p = 0.0133). This indicated that the predicted influence of HIV-related stigma on HRQoL via depression had negative effect on HRQoL for individuals with low social support. The results suggest that social support can buffer the negative impact of depression on HRQoL and highlights the need for future interventions to target these psychosocial factors in order to improve HRQoL among incarcerated PLH.

Indexed as

Social StigmaSocial SupportAdultAsian PeopleDepressionDepressive DisorderHealth StatusHIV InfectionsHumansLeast-Squares AnalysisMalaysiaMaleMiddle AgedOpioid-Related DisordersPrisonersQuality of LifeDepressionHealth-related quality of lifeHIV-related stigmaPrisonersSocial support

Identifiers

PMID28108877
PMCPMC5344717
OpenAlexW2574276257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.