Trial reportInternational orthopaedics2017
A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years.
Trial report in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02993510 (Randomised Multi-Center Study), which is not on this map. Cited by 90 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003
Who cites it
90 citing papers in PubMed, 13 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Surgery for early structural osteoarthritis of the hip and knee: the SCORE evidence synthesis and economic evaluation.Health technology assessment (Winchester, England) · 2026Pooled it
- Pooled it
- The use of autologous chondrocyte transplantation for the treatment of osteoarthritis: a systematic review of clinical trials.Cell and tissue banking · 2024Pooled it
- Prognostic factors for the management of chondral defects of the knee and ankle joint: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Surgical strategies for chondral defects of the patellofemoral joint: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Autologous matrix-induced chondrogenesis is effective for focal chondral defects of the knee.Scientific reports · 2022Pooled it
- Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.British medical bulletin · 2022Pooled it
- Chondral injuries in patients with recurrent patellar dislocation: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee.Cartilage · 2021Pooled it
- Matrix-induced chondrogenesis is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Cell-Free Scaffolds in Cartilage Knee Surgery: A Systematic Review and Meta-Analysis of Clinical Evidence.Cartilage · 2021Pooled it
- Pooled it
- Surgical interventions for symptomatic mild to moderate knee osteoarthritis.The Cochrane database of systematic reviews · 2019Pooled it
- A prospective randomized controlled trial comparing biphasic cartilage repair implant with microfracture in small chondral lesions of knee: findings at five-year-follow-up.Journal of orthopaedic surgery and research · 2025Trial
- A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMICEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Trial
- Trial
- Arthroscopic microfracture with atelocollagen augmentation for osteochondral lesion of the talus: a multicenter randomized controlled trial.BMC musculoskeletal disorders · 2020Trial
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- Synovial Fluid as a Window into Early Cartilage Remodeling After Autologous Matrix-Induced Chondrogenesis.Medicina (Kaunas, Lithuania) · 2026Article
- Replicability of Highly Cited Comparative Studies in Orthopedic Journals.HCA healthcare journal of medicine · 2026Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAutologous Matrix-Induced Chondrogenesis (AMIC
methodsForty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm
resultsAfter improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC
conclusionsAMIC
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.