ArticleIntensive care medicine2017
Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.
Article in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01093482 (Third Prospective, Observational, International, Multicenter Study on Mechanical Ventilation), which is not on this map. Cited by 129 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Third Prospective, Observational, International, Multicenter Study on Mechanical Ventilation
Who cites it
129 citing papers in PubMed, 2 syntheses or guidelines pooled it, 219 citations in OpenAlex.
- The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis.Intensive care medicine · 2022Pooled it
- Carbon dioxide levels in neonates: what are safe parameters?Pediatric research · 2022Pooled it
- Extracorporeal Multiorgan Support During Prone Positioning in Severe ARDS: A Physiologic Proof-of-Concept Study.Life (Basel, Switzerland) · 2026Article
- Effects of PERMISSive lung-protective ventilation on outcome in critically ill, invasively ventilated patients (PERMISS): protocol for a feasibility and safety randomised clinical trial.BMJ open respiratory research · 2026Article
- Intraoperative mechanical ventilation management in COPD: A state of the art review.Clinics (Sao Paulo, Brazil) · 2026Review
- Therapeutic Strategy of Extracorporeal Carbon Dioxide Removal in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Combined With Central Airway Stricture: A Case Report.Respirology case reports · 2026Article
- Autophagic flux blockade under hypocapnia reveals CO2-sensitive regulation of autophagy-lysosome homeostasis.Biology open · 2026Article
- Severe hypercapnia and hemodynamic instability following a sudden elevation in end-tidal CO₂ during thoraco-laparoscopic esophagectomy: a case report and literature review.BMC cardiovascular disorders · 2026Review
- PaCOJournal of clinical medicine · 2026Review
- Obstructive Sleep Apnea in Critically Ill Patients: A Structured Narrative Review of Prevalence, Diagnostic Barriers, and Clinical Implications in the ICU.Clocks & sleep · 2026Review
- Minimally invasive extracorporeal COCritical care (London, England) · 2026Observational
- Coupled mixed-dimensional multiphase porous media approach for modeling airflow, blood flow, and gas exchange in the human lungs.Biomechanics and modeling in mechanobiology · 2026Article
- Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026Review
- PaCOFrontiers in medicine · 2026Review
- Long-term DNA methylation changes induced by age and elevated COSkeletal muscle · 2025Article
- Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study.BMC anesthesiology · 2025Article
- Length of stay, duration of mechanical ventilation, mortality, and acute kidney injury in acute respiratory failure requiring endotracheal intubation.World journal of critical care medicine · 2025Article
- Ventilator-Associated Lung Injury: Pathophysiology, Prevention, and Emerging Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Hypercapnia as a Double-Edged Modulator of Innate Immunity and Alveolar Epithelial Repair: A PRISMA-ScR Scoping Review.International journal of molecular sciences · 2025Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 20 institutions in 23 countries.
Funding
Abstract
purposeTo analyze the relationship between hypercapnia developing within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS). PATIENTS AND
methodsWe performed a secondary analysis of three prospective non-interventional cohort studies focusing on ARDS patients from 927 intensive care units (ICUs) in 40 countries. These patients received mechanical ventilation for more than 12 h during 1-month periods in 1998, 2004, and 2010. We used multivariable logistic regression and a propensity score analysis to examine the association between hypercapnia and ICU mortality. MAIN OUTCOMES: We included 1899 patients with ARDS in this study. The relationship between maximum PaCO
conclusionsSevere hypercapnia appears to be independently associated with higher ICU mortality in patients with ARDS.
trial registrationClinicaltrials.gov identifier, NCT01093482.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.