Evidence map›Paper›PMID 28108637›Full record

ArticleNeurology2017

Lei Yu, Michael W Lutz, Robert S Wilson, Daniel K Burns, Allen D Roses, Ann M Saunders, Chris Gaiteri, Philip L De Jager, Lisa L Barnes, David A Bennett

Open access · bronzeAbstract read
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 71 citations in OpenAlex.

  1. Trial
  2. Article
  3. Biological psychiatry global open science · 2026
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  6. MIND diet, cerebrovascular health, and cognition among community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Arachnoid granulation morphologies and β-amyloid and tau pathology in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  8. Article
  9. bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Journal of the American Heart Association · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Lei YuFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA. lei_yu@Rush.edu.
Michael W LutzFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Robert S WilsonFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Daniel K BurnsFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Allen D RosesFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Ann M SaundersFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Chris GaiteriFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Philip L De JagerFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Lisa L BarnesFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
David A BennettFrom the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.
Harvard University · USBrigham and Women's Hospital · USDuke University · USResearch Triangle Park Foundation · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
Racial Differences in Late-Life Cognitive Decline and Risk of Alzheimer's DiseaseRF1AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2016 to 2019
$6.6M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG022018
6 · The paper itself

Abstract

objectiveTo interrogate a poly-T variant (rs10524523, '523) in

methodsData came from participants in 2 cohort studies of aging and dementia who underwent annual clinical evaluations for up to 21 years.

resultsThe 1,170

conclusionsOur data reveal an association of

Indexed as

Genetic VariationHomozygoteAgedApolipoprotein E3CognitionCognitive DysfunctionCohort StudiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotyping TechniquesHumansLinear ModelsMaleMembrane Transport ProteinsMental Status ScheduleApolipoprotein E3Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsTOMM40 protein, human

Identifiers

PMID28108637
PMCPMC5317377
OpenAlexW2574723258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.