Evidence map›Paper›PMID 28108621›Full record

ArticleThorax2017

Are physical measures related to patient-centred outcomes in ARDS survivors?

Kitty S Chan, Lisa Aronson Friedman, Victor D Dinglas, Catherine L Hough, Carl Shanholtz, E Wesley Ely, Peter E Morris, Pedro A Mendez-Tellez, James C Jackson, Ramona O Hopkins and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Thorax, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Physical function measures in ICU survivors, where to now? A scoping review.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024
    Article
  6. Article
  7. Interrelationships among workload, illness severity, and function on return to work following acute respiratory distress syndrome.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. [Life after ARDS].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kitty S ChanDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Lisa Aronson FriedmanOutcomes after Critical Illness and Surgery Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Victor D DinglasOutcomes after Critical Illness and Surgery Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Catherine L HoughDivision of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, Washington, USA.
Carl ShanholtzDivision of Pulmonary and Critical Care Medicine, University of Maryland, Baltimore, Maryland, USA.
E Wesley ElyDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Peter E MorrisDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, Kentucky, USA.
Pedro A Mendez-TellezOutcomes after Critical Illness and Surgery Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
James C JacksonDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Ramona O HopkinsDepartment of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, Utah, USA.
Dale M NeedhamOutcomes after Critical Illness and Surgery Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHESP50HL073994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BROWER, ROY G. · 2003 to 2007
$21.3M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
Improving Long-Term Outcomes Clinical Research for Acute Respiratory FailureR24HL111895 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NEEDHAM, DALE MURRAY · 2013 to 2017
$5.4M
Improving Long-Term Physical and Mental Health after Acute Lung InjuryR01HL088045 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NEEDHAM, DALE MURRAY, PRONOVOST, PETER J. · 2008 to 2011
$3.1M
Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsR01HL091760 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HOPKINS, RAMONA O, NEEDHAM, DALE MURRAY · 2008 to 2011
$2.0M
ICU-ACQUIRED NEUROMUSCULAR DYSFUNCTION AND OUTCOMES IN ACUTE LUNG INJURYR01HL096504 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, NEEDHAM, DALE MURRAY · 2010 to 2013
$1.5M
NCATS NIH HHS UL1 TR000424NHLBI NIH HHS P50 HL073994NHLBI NIH HHS R01 HL088045NHLBI NIH HHS R01 HL091760NHLBI NIH HHS R01 HL096504NHLBI NIH HHS R24 HL111895
6 · The paper itself

Abstract

objectiveTo inform selection of physical measures for studies of acute respiratory distress syndrome (ARDS) survivors within 12 months of ARDS.

methodsSecondary analysis of data from 6-month survivors participating in a US multicentre prospective study (ARDSNet Long-Term Outcome Study, N=134) or a multisite prospective study in Baltimore, Maryland, USA (Improving Care of Acute Lung Injury Patients, N=99). Physical measures, assessed at 6-month follow-up, were categorised according to the WHO's International Classification of Disability and Health: body functions and structures, activity and participation. Patient-centred outcomes were evaluated at 6 and 12 months: survival, hospitalisation, alive at home status and health-related quality of life. Pearson correlation, linear and logistic regression models were used to quantify associations of physical measures with patient-centred outcomes. MAIN

resultsNo 6-month body functions and structures measure demonstrated consistent association with 6-month or 12-month outcomes in multivariable regression. The 6 min walk test, an activity measure, was associated with 6-month Short-Form 36 (SF-36) physical component scores (PCS, β range: 0.99 to 1.52, p<0.05). Participation measures (Functional Performance Inventory, FPI; Instrumental Activities of Daily Living, IADLs) were associated with SF-36 PCS (β range: FPI, 1.51-1.52; IADL, -1.88 to -1.32; all p<0.05) and Euro-QOL-5D utility score (β range: FPI, 2.00-3.67; IADL, -2.89 to -2.50; all p<0.01) at 6 and 12 months.

conclusionsParticipation measures better reflect patient's quality of life than measures of body functions and structures within 12 months of ARDS among 6-month survivors, and are recommended for inclusion as a core measure in future studies.

Indexed as

Activities of Daily LivingQuality of LifeSurvivorsBaltimoreDisability EvaluationFemaleHumansMaleMiddle AgedPatient Outcome AssessmentProspective StudiesRespiratory Distress SyndromeUnited StatesARDS

Identifiers

PMID28108621
PMCPMC6888961

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.