Evidence map›Paper›PMID 28108608›Full record

ArticleDiabetes2017

Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice.

Brian F Zamarron, Taleen A Mergian, Kae Won Cho, Gabriel Martinez-Santibanez, Danny Luan, Kanakadurga Singer, Jennifer L DelProposto, Lynn M Geletka, Lindsey A Muir, Carey N Lumeng

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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  6. Review
  7. Article
  8. Article
  9. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Brian F ZamarronGraduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0001-6549-4230
Taleen A MergianCollege of Literature Sciences and Arts, University of Michigan, Ann Arbor, MI.
Kae Won ChoSoonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan-si, Chungcheongnam-do, Korea.
Gabriel Martinez-SantibanezDepartment of Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI.
Danny LuanCollege of Literature Sciences and Arts, University of Michigan, Ann Arbor, MI.
Kanakadurga SingerGraduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0001-8728-3800
Jennifer L DelPropostoDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI.
Lynn M GeletkaDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI.
Lindsey A MuirDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0002-1756-0325
Carey N LumengGraduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI clumeng@umich.edu.ORCID 0000-0003-0303-2604
University of Michigan · USSoonchunhyang University · KR

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
Regulation of Adipose Tissue Inflammation By Antigen Presenting CellsR01DK090262 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, CAREY N · 2011 to 2024
$5.3M
Multidisciplinary Training Program in Basic Diabetes ResearchT32DK101357 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN, Ormond A MacDougald · 2014 to 2026
$4.1M
Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
Mechanisms of hematopoietic stem cell activation in obesityK08DK101755 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SINGER, KANAKADURGA · 2015 to 2018
$644k
Regulation of lipid laden adipose tissue macrophages in metabolic dysfunctionF32DK105676 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUIR, LINDSEY ALLISON · 2015 to 2016
$112k
Regulation of Obesity-Induced Adipose Tissue Inflammation During Weight LossF31DK103524 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZAMARRON, BRIAN FRANCIS · 2014 to 2016
$90k
NIAID NIH HHS T32 AI007413NIDDK NIH HHS F31 DK103524NIDDK NIH HHS F32 DK105676NIDDK NIH HHS R01 DK090262NIDDK NIH HHS T32 DK101357
6 · The paper itself

Abstract

Obesity causes dramatic proinflammatory changes in the adipose tissue immune environment, but relatively little is known regarding how this inflammation responds to weight loss (WL). To understand the mechanisms by which meta-inflammation resolves during WL, we examined adipose tissue leukocytes in mice after withdrawal of a high-fat diet. After 8 weeks of WL, mice achieved similar weights and glucose tolerance values as age-matched lean controls but showed abnormal insulin tolerance. Despite fat mass normalization, total and CD11c

Indexed as

Cell ProliferationAdipose TissueAnimalsBody WeightDiet, High-FatFlow CytometryFluorescent Antibody TechniqueGene Expression ProfilingGlucose Tolerance TestHomeodomain ProteinsImmunoblottingImmunohistochemistryInflammationInsulinInterferon-gammaInterleukin-1betaHomeodomain ProteinsIL1B protein, mouseInsulinInterferon-gammaInterleukin-1betaRAG-1 proteinTumor Necrosis Factor-alpha

Identifiers

PMID28108608
PMCPMC5248991
OpenAlexW2551984653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.