Evidence map›Paper›PMID 28108589›Full record

ArticleGenetics2017

Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1.

Naomi E Searle, Ana Lilia Torres-Machorro, Lorraine Pillus

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Cryo-EM structures reveal the acetylation process of piccolo NuA4.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. The histone code of the fungal genusMicrobial genomics · 2022
    Article
  11. eLife · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Naomi E SearleBiomedical Sciences, University of California, San Diego, La Jolla, California 92093.ORCID 0000-0002-5208-9700
Ana Lilia Torres-MachorroSection of Molecular Biology, Division of Biological Sciences, University of California, San Diego, UC San Diego Moores Cancer Center, La Jolla, California 92093.ORCID 0000-0003-3100-6897
Lorraine PillusSection of Molecular Biology, Division of Biological Sciences, University of California, San Diego, UC San Diego Moores Cancer Center, La Jolla, California 92093 lpillus@ucsd.edu.ORCID 0000-0002-8818-5227
Moores Cancer CenterUniversity of California, San Diego · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
NCI NIH HHS P30 CA023100NIGMS NIH HHS T32 GM008666
6 · The paper itself

Abstract

Enzymes that modify and remodel chromatin act in broadly conserved macromolecular complexes. One key modification is the dynamic acetylation of histones and other chromatin proteins by opposing activities of acetyltransferase and deacetylase complexes. Among acetyltransferases, the NuA4 complex containing Tip60 or its

Indexed as

Binding SitesChromatin Assembly and DisassemblyHistone AcetyltransferasesProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsEpl1 protein, S cerevisiaeEsa1 protein, S cerevisiaeHistone AcetyltransferasesNuA4 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsacetylationchromatinEPL1ESA1NuA4

Identifiers

PMID28108589
PMCPMC5340328
OpenAlexW2571712407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.