ArticleGenetics2017
Inferring Recent Demography from Isolation by Distance of Long Shared Sequence Blocks.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Blocks of Identity by Descent Reveal the Dual Role Played by Reef Fish Larvae for Retention and Dispersal.Molecular ecology · 2026Article
- Comparing the genomic inbreeding of an isolated rhesus macaque study population to wild populations.bioRxiv : the preprint server for biology · 2026Article
- Analysis of medieval burials from Ibiza reveals genetic and pathogenic diversity during the Islamic period.Nature communications · 2026Article
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- Identifying Single-Origin Rare Variants in Population Genomic Data.Molecular biology and evolution · 2025Article
- Ancient genomes provide evidence of demographic shift to Slavic-associated groups in Moravia.Genome biology · 2025Article
- Population genomics of Aedes albopictus across remote Pacific islands for genetic biocontrol considerations.PLoS neglected tropical diseases · 2025Article
- Sweeps in Space: Leveraging Geographic Data to Identify Beneficial Alleles in Anopheles gambiae.Molecular biology and evolution · 2025Article
- Using isolation-by-distance to jointly estimate effective population density and dispersal distance: a practical evaluation using bumble bees.Oecologia · 2025Article
- sandwrm: an R package for estimating Wright's neighborhood size and species-level genetic diversity.bioRxiv : the preprint server for biology · 2025Article
- Estimating effective population size trajectories from time-series identity-by-descent segments.Genetics · 2025Article
- Estimating realized relatedness in free-ranging macaques by inferring identity-by-descent segments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The genetic demographic history of the last hunter-gatherer population of the Himalayas.Scientific reports · 2025Article
- Establishment of a locally adaptive allele in multidimensional continuous space.G3 (Bethesda, Md.) · 2025Article
- Article
- Estimation of spatial demographic maps from polymorphism data using a neural network.Molecular ecology resources · 2024Article
- A spatial approach to jointly estimate Wright's neighborhood size and long-term effective population size.Genetics · 2024Article
- Taking identity-by-descent analysis into the wild: Estimating realized relatedness in free-ranging macaques.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
3 authors.
Funding
Abstract
Recently it has become feasible to detect long blocks of nearly identical sequence shared between pairs of genomes. These identity-by-descent (IBD) blocks are direct traces of recent coalescence events and, as such, contain ample signal to infer recent demography. Here, we examine sharing of such blocks in two-dimensional populations with local migration. Using a diffusion approximation to trace genetic ancestry, we derive analytical formulas for patterns of isolation by distance of IBD blocks, which can also incorporate recent population density changes. We introduce an inference scheme that uses a composite-likelihood approach to fit these formulas. We then extensively evaluate our theory and inference method on a range of scenarios using simulated data. We first validate the diffusion approximation by showing that the theoretical results closely match the simulated block-sharing patterns. We then demonstrate that our inference scheme can accurately and robustly infer dispersal rate and effective density, as well as bounds on recent dynamics of population density. To demonstrate an application, we use our estimation scheme to explore the fit of a diffusion model to Eastern European samples in the Population Reference Sample data set. We show that ancestry diffusing with a rate of [Formula: see text] during the last centuries, combined with accelerating population growth, can explain the observed exponential decay of block sharing with increasing pairwise sample distance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.