Evidence map›Paper›PMID 28108569›Full record

ArticleThe British journal of ophthalmology2017

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report.

Nichole Joachim, Johanna Maria Colijn, Annette Kifley, Kristine E Lee, Gabriëlle H S Buitendijk, Barbara E K Klein, Chelsea E Myers, Stacy M Meuer, Ava G Tan, Elizabeth G Holliday and 10 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Trial
  2. Article
  3. Eye Dominance and Testing Order Effects in the Circularly-Oriented Macular Pigment Optical Density Measurements.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  4. Clinical course of non-exudative macular neovascularisations in sustained unilateral neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  5. Article
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  8. Review
  9. Article
  10. Article
  11. Article
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  17. Observational
  18. Life (Basel, Switzerland) · 2022
    Article
  19. Molecules (Basel, Switzerland) · 2022
    Article
  20. [Real-life results of anti-VEGF treatment in fellow eyes with nAMD].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nichole JoachimCentre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Johanna Maria ColijnDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Annette KifleyCentre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Kristine E LeeDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin, USA.
Gabriëlle H S BuitendijkDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-6212-9403
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin, USA.
Chelsea E MyersDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin, USA.
Stacy M MeuerDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin, USA.
Ava G TanCentre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Elizabeth G HollidayCentre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
John AttiaCentre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
Gerald LiewCentre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Sudha K IyengarDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
Paulus T V M de JongNetherlands Institute of Neuroscience of the Royal Netherlands Academy of Arts and Sciences (KNAW), Departments of Ophthalmology AMC, Amsterdam and LUMC, Leiden, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Johannes R VingerlingDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Paul MitchellCentre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Caroline C W KlaverDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin, USA.
Jie Jin WangCentre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.

Funding

THE EPIDEMIOLOGY OF AGE-RELATED OCULAR DISEASEU10EY006594 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, RONALD · 1987 to 2018
$17.3M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
NEI NIH HHS P30 EY016665NEI NIH HHS U10 EY006594Wellcome Trust
6 · The paper itself

Abstract

purposeTo assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors.

designPooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study.

methodsRetinal photography and interview with comprehensive questionnaires were conducted at each visit of three studies. AMD was assessed following the modified Wisconsin AMD grading protocol. Progression to bilateral any (early and late) or late AMD was assessed among participants with unilateral involvement only. Factors associated with the progression were assessed using logistic regression models while simultaneously adjusting for other significant risk factors.

resultsIn any 5-year duration, 19-28% of unilateral any AMD cases became bilateral and 27-68% of unilateral late AMD became bilateral. Factors associated with the progression to bilateral involvement of any AMD were age (per year increase, adjusted OR 1.07), carrying risk alleles of the

conclusionOne in four to one in five unilateral any AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement.

Indexed as

AdultAgedAged, 80 and overAge FactorsCohort StudiesComplement Factor HDisease ProgressionFemaleFollow-Up StudiesGenotyping TechniquesHumansIncidenceMacular DegenerationMaleMiddle AgedPhotographyARMS2 protein, humanCFH protein, humanComplement Factor HProteinsDegenerationEpidemiologyMacula

Identifiers

PMID28108569
PMCPMC5869687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.