Evidence map›Paper›PMID 28108559›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant αβ TCRs Specific for a Conserved Peptide-Qa-1

Jian Guan, Soo Jung Yang, Federico Gonzalez, Yuxin Yin, Nilabh Shastri

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. CD8+ Regulatory T Cells.Annual review of immunology · 2026
    Review
  2. Article
  3. Unconventional CD8Science advances · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Innate and Innate-like Effector Lymphocytes in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  11. Review
  12. Review
  13. Mobilizing unconventional T cells.Science (New York, N.Y.) · 2019
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jian GuanInstitute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China; and.
Soo Jung YangDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720.ORCID 0000-0002-4355-5079
Federico GonzalezDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720.
Yuxin YinInstitute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China; and yinyuxin@bjmu.edu.cn nshastri@berkeley.edu.
Nilabh ShastriDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 yinyuxin@bjmu.edu.cn nshastri@berkeley.edu.
University of California, Berkeley · USPeking University · CN

Funding

Antigen Processing in the Secretory PathwayR37AI060040 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SADEGH-NASSERI, SCHEHERAZADE · 2012 to 2021
$4.2M
Immune Surveillance of Antigen Processing PathwayR01AI130210 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SADEGH-NASSERI, SCHEHERAZADE · 2017 to 2021
$2.8M
Antigen processing in the secretory pathwayR01AI060040 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SHASTRI, NILABH · 2004 to 2010
$2.4M
Immune surveillance via non-classical MHC class Ib moleculesR21AI101751 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SHASTRI, NILABH · 2012 to 2013
$411k
NIAID NIH HHS R01 AI060040NIAID NIH HHS R01 AI130210NIAID NIH HHS R21 AI101751NIAID NIH HHS R37 AI060040
6 · The paper itself

Abstract

Ag processing in the endoplasmic reticulum (ER) by the ER aminopeptidase associated with Ag processing (ERAAP) is central to presentation of a normal peptide-MHC class I (MHC I) repertoire. Alternations in ERAAP function cause dramatic changes in the MHC I-presented peptides, which elicit potent immune responses. An unusual subset of CD8

Indexed as

Antigen PresentationAnimalsAntigensCD8-Positive T-LymphocytesCells, CulturedConserved SequenceEndoplasmic ReticulumGenetic VariationHistocompatibility Antigens Class ILeucyl AminopeptidaseLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicPeptidesReceptors, Antigen, T-Cell, alpha-betaAntigensHistocompatibility Antigens Class ILeucyl AminopeptidasePeptidespuromycin-insensitive leucyl-specific aminopeptidaseQ surface antigensReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID28108559
PMCPMC5321846
OpenAlexW2588427921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.