ArticleJournal of the American Heart Association2017
Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mobile health technologies to improve walking distance in people with intermittent claudication.The Cochrane database of systematic reviews · 2024Pooled it
- Quality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial.The American journal of cardiology · 2024Trial
- Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study.Medicina (Kaunas, Lithuania) · 2023Trial
- A multicenter, randomized, open-labelled, non-inferiority trial of sustained-release sarpogrelate versus clopidogrel after femoropopliteal artery intervention.Scientific reports · 2023Trial
- Trial
- Walking Training Improves Ambulatory Blood Pressure Variability in Claudication.Arquivos brasileiros de cardiologia · 2021Trial
- Establishing Thresholds for Minimal Clinically Important Differences for the Peripheral Artery Disease Questionnaire.Circulation. Cardiovascular quality and outcomes · 2021Trial
- Trial
- Trial
- Daily Passive Muscle Stretching Improves Flow-Mediated Dilation of Popliteal Artery and 6-minute Walk Test in Elderly Patients with Stable Symptomatic Peripheral Artery Disease.Cardiovascular revascularization medicine : including molecular interventions · 2019Trial
- A Novel, Individualized Exercise Program for Patients with Peripheral Arterial Disease Recovering from Bypass Surgery.International journal of environmental research and public health · 2019Trial
- The Role of Home-Based Exercise in the Management of Peripheral Artery Disease.Current treatment options in cardiovascular medicine · 2026Article
- Enrollment of Historically Underrepresented Groups in Peripheral Arterial Disease Trials: A Systematic Review.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Review
- Whole-body vibration training on functional capacity, vascular function, and glycemic control in individuals with type 2 diabetes and peripheral arterial disease: protocol for a randomized controlled trial.Frontiers in endocrinology · 2026Article
- Prevalence of peripheral arterial disease and associated factors among hypertensive patients attending two tertiary hospitals of Addis Ababa, Ethiopia.BMC cardiovascular disorders · 2025Article
- Trends of the burden, risk factors, and future projections of peripheral artery disease in the elderly.BMC geriatrics · 2025Article
- Comparative Analysis of Mortality and Amputation Rates in Patients Undergoing Atherectomy for Infra-Popliteal Peripheral Arterial Disease: Insight From the VQI.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2025Article
- Global, regional, and national trends in peripheral arterial disease among older adults: findings from the global burden of disease study 2021.Aging clinical and experimental research · 2025Article
- Association of Ankle-Brachial Index with Quality of Life and Survival Outcomes in Hemodialysis Patients.Journal of clinical medicine · 2025Article
- Impact of Panvascular Disease on Exercise Capacity and Clinical Outcomes in Patients with Heart Failure with Reduced Ejection Fraction.CJC open · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundEvidence regarding the association of lower extremity peripheral arterial disease with quality of life (QOL) is mainly from selected clinical populations or relatively small clinical cohorts. Thus, we investigated this association in community-derived populations. METHODS AND
resultsUsing data of 5115 participants aged 66 to 90 years from visit 5 (2011-2013) of the Atherosclerosis Risk in Communities Study, we quantified the associations of ankle-brachial index (ABI) with several QOL parameters, including 12-item Short-Form Health Survey (SF-12), after accounting for potential confounders using linear and logistic regression models. Peripheral arterial disease defined by an ABI <0.90 (n=402), was independently associated with a low SF-12 Physical Component Summary score (-3.26 [95% CI -5.60 to -0.92]), compared to the ABI reference 1.10 to 1.19 (n=1900) but not with the Mental Component Summary score (-0.07 [-2.21 to 2.06]). A low ABI was significantly associated with poorer status of all SF-12 physical domains (physical functioning, role-physical, bodily pain, and general health) but only vitality out of 4 mental domains. Similarly, low ABI values were more consistently associated with other physically related QOL parameters (leisure-time exercise/activity/walking) than mentally related parameters (significant depressive symptoms and hopeless feeling). Lower physical QOL was observed even in individuals with borderline low ABI (0.90 to 0.99; n=426).
conclusionsLow ABI (even borderline) was independently associated with poor QOL, especially for physical components, in community-dwelling older adults. QOL is a critical element for older adults, and thus, further studies are warranted to assess whether peripheral arterial disease-specific management can improve QOL in older populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.