Trial reportThe journal of pain2017
Trajectory of Improvement in Children and Adolescents With Chronic Migraine: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial.
Trial report in The journal of pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00389038 (Drug and Non-Drug Treatment of Pediatric Chronic Headache), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Drug and Non-Drug Treatment of Pediatric Chronic Headache
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Cognitive Behavioral Therapy for Children With Headaches: Will an App Do the Trick?Journal of child neurology · 2023Trial
- Article
- Current Trends in Pediatric Migraine: Clinical Insights and Therapeutic Strategies.Brain sciences · 2025Review
- Behavioral therapy in migraine: Expanding the therapeutic arsenal.European journal of neurology · 2024Review
- Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024Review
- From the New Diagnostic Criteria to COVID-19 Pandemic Passing Through the Placebo Effect. What Have We Learned in the Management of Pediatric Migrane Over the Past 5 Years?Frontiers in neurology · 2022Review
- Management of Chronic Migraine in Children and Adolescents: Where are We in 2022?Pediatric health, medicine and therapeutics · 2022Review
- Non-Pharmacological Approaches to Headaches: Non-Invasive Neuromodulation, Nutraceuticals, and Behavioral Approaches.International journal of environmental research and public health · 2021Review
- Breakthroughs on the clinical management of headache and questions that need to be solved.Ibrain · 2021Review
- Review
- Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?Frontiers in neurology · 2019Review
- Recommendations on the Use of Anti-CGRP Monoclonal Antibodies in Children and Adolescents.Headache · 2018Article
- The Effects of Chronic Amitriptyline on Zebrafish Behavior and Monoamine Neurochemistry.Neurochemical research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
We compared headache frequency trajectories between clinical trial participants who received cognitive-behavioral therapy (CBT) and amitriptyline (CBT+A) or headache education (HE) and amitriptyline (HE+A) to determine if there was a differential time course of treatment response between the groups. One hundred thirty-five patients (age 10-17 years) diagnosed with chronic migraine participated, attending 8 one-hour one-on-one CBT or HE sessions with a trained psychologist for 8 weekly sessions, 2 sessions at weeks 12 and 16, and a post-treatment visit at week 20. Participants kept daily headache diaries and completed take-home assignments between visits. Data from daily headache diaries are presented for each day and according to 28-day periods. Trajectories of improvement indicate initial decrease in headache days began during the first month of treatment, for both groups, and continued to decrease throughout treatment. The CBT+A group had greater daily improvement than the HE+A group. A significantly greater proportion of the CBT+A group had a ≥50% reduction in headache days each month, and a significantly greater proportion of the CBT+A group had ≤4 headache days per month in months 3 through 5. Results indicate the trajectory of decrease in headache days is significantly better for patients receiving CBT+A versus HE+A. PERSPECTIVE: This article presents daily information about headache frequency over a 20-week clinical trial. Youth with chronic migraine who received CBT+A improved faster than those in the control group. Findings provide clinicians with evidence-based expectations for treatment response over time and ways of monitoring treatment success.
trial registrationclinicaltrials.gov identifier NCT00389038.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.