Evidence map›Paper›PMID 28108291›Full record

ArticleNeurobiology of disease2017

Neuroendocrine signaling modulates specific neural networks relevant to migraine.

Margarida Martins-Oliveira, Simon Akerman, Philip R Holland, Jan R Hoffmann, Isaura Tavares, Peter J Goadsby

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Molecular Mechanisms of Migraine: Nitric Oxide Synthase and Neuropeptides.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Headache in people with epilepsy.Nature reviews. Neurology · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Margarida Martins-OliveiraHeadache Group, Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, UK; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Experimental Biology, Faculty of Medicine of University of Porto, Institute for Molecular and Cell Biology (IBMC) and Institute of Investigation and Innovation in Health (i3S), University of Porto, Porto, Portugal.
Simon AkermanDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Philip R HollandHeadache Group, Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, UK.
Jan R HoffmannDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Isaura TavaresDepartment of Experimental Biology, Faculty of Medicine of University of Porto, Institute for Molecular and Cell Biology (IBMC) and Institute of Investigation and Innovation in Health (i3S), University of Porto, Porto, Portugal.
Peter J GoadsbyHeadache Group, Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, UK; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: peter.goadsby@kcl.ac.uk.
University of California, San Francisco · USi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTKing's College London · GB

Funding

Wellcome Trust 104033
6 · The paper itself

Abstract

Migraine is a disabling brain disorder involving abnormal trigeminovascular activation and sensitization. Fasting or skipping meals is considered a migraine trigger and altered fasting glucose and insulin levels have been observed in migraineurs. Therefore peptides involved in appetite and glucose regulation including insulin, glucagon and leptin could potentially influence migraine neurobiology. We aimed to determine the effect of insulin (10U·kg

Indexed as

Analgesics, Non-NarcoticAnimalsArcuate Nucleus of HypothalamusGlucagonHypothalamusInsulinLeptinMaleMAP Kinase Signaling SystemMigraine DisordersNeural PathwaysNeuronsPainRats, Sprague-DawleyTrigeminal NucleiAnalgesics, Non-NarcoticGlucagonInsulinLeptinAppetiteGlucoseHeadacheMigrainepERK1/2Trigeminovascular activation

Identifiers

PMID28108291
PMCPMC5356993
OpenAlexW2579490507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.