Evidence map›Paper›PMID 28108278›Full record

ArticleFree radical biology & medicine2017

Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.

N Connor Payne, Andrew Geissler, Aileen Button, Alexandru R Sasuclark, Alayne L Schroll, Erik L Ruggles, Vadim N Gladyshev, Robert J Hondal

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Mechanistic Insights Into the Oxidative Reactivity of 2-Selenouridine in tRNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
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  2. Review
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  7. Optimized Biocatalytic Synthesis of 2-Selenopyrimidine Nucleosides by Transglycosylation*.Chembiochem : a European journal of chemical biology · 2021
    Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

N Connor PayneDepartment of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States.
Andrew GeisslerDepartment of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States.
Aileen ButtonDepartment of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States.
Alexandru R SasuclarkDepartment of Chemistry, St. Michael's College, 1 Winooski Park, Colchester, VT 05439, United States.
Alayne L SchrollDepartment of Chemistry, St. Michael's College, 1 Winooski Park, Colchester, VT 05439, United States.
Erik L RugglesDepartment of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Robert J HondalDepartment of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States. Electronic address: Robert.Hondal@uvm.edu.
Saint Michael's College · USHarvard University · US

Funding

The Biological and Chemical Function of Selenium in EnzymesR01GM094172 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HONDAL, ROBERT J · 2010 to 2013
$1.3M
NIGMS NIH HHS R01 GM094172
6 · The paper itself

Abstract

Selenium is present in proteins in the form of selenocysteine, where this amino acid serves catalytic oxidoreductase functions. The use of selenocysteine in nature is strongly associated with redox catalysis. However, selenium is also found in a 2-selenouridine moiety at the wobble position of tRNA

Indexed as

GlutathioneHydrogen PeroxideMagnetic Resonance SpectroscopyOrganoselenium CompoundsOxidation-ReductionOxidative StressRNA, TransferSeleniumSelenocysteineSulfurUracilUridine2-selenouridineGlutathioneHydrogen PeroxideOrganoselenium CompoundsRNA, TransferSeleniumSelenocysteineSulfurUracilUridineOxidative stressSelenocysteineSelenouridineSignalingThiouridine

Identifiers

PMID28108278
PMCPMC5328918
OpenAlexW2573557544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.