ArticlePharmacology, biochemistry, and behavior2017
Differential housing and novelty response: Protection and risk from locomotor sensitization.
Article in Pharmacology, biochemistry, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.Frontiers in veterinary science · 2022Pooled it
- Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.Psychopharmacology · 2021Pooled it
- Locomotor Response to Novelty: What Does It Tell Us?Developmental psychobiology · 2025Article
- Effects of repeated voluntary oral consumption of synthetic delta-9-tetrahydrocannabinol on locomotor activity and cannabinoid receptor 1 expression.Behavioural brain research · 2025Article
- Effects of social housing conditions on ethanol-induced behavioral sensitization in Swiss mice.Psychopharmacology · 2024Article
- Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats.Scientific reports · 2024Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates.Journal of clinical medicine · 2022Article
- Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations.The European journal of neuroscience · 2021Article
- The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat.Frontiers in behavioral neuroscience · 2021Article
- Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats.Frontiers in behavioral neuroscience · 2020Article
- Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens.Psychopharmacology · 2019Article
- Voluntary ethanol consumption during early social isolation and responding for ethanol in adulthood.Alcohol (Fayetteville, N.Y.) · 2019Article
- Integrated Effects of Neonatal Ventral Hippocampal Lesions and Impoverished Social-Environmental Rearing on Endophenotypes of Mental Illness and Addiction Vulnerability.Developmental neuroscience · 2019Article
- Environmental Enrichment During Adolescence Acts as a Protective and Therapeutic Tool for Ethanol Binge-Drinking, Anxiety-Like, Novelty Seeking and Compulsive-Like Behaviors in C57BL/6J Mice During Adulthood.Frontiers in behavioral neuroscience · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
High novelty seeking increases the risk for drug experimentation and locomotor sensitization. Locomotor sensitization to psychostimulants is thought to reflect neurological adaptations that promote the transition to compulsive drug taking. Rats reared in enrichment (EC) show less locomotor sensitization when compared to rats reared in isolation (IC) or standard conditions (SC). The current research study was designed to test if novelty response contributed locomotor sensitization and more importantly, if the different housing environments could change the novelty response to protect against the development of locomotor sensitization in both adolescence and adulthood. Experiment 1: rats were tested for their response to novelty using the inescapable novelty test (IEN) and pseudorandomly assigned to enriched (EC), isolated (IC), or standard (SC) housing conditions for 30days. After housing, they were tested with IEN. Rats were then administered amphetamine (0.5mg/kg) or saline and locomotor activity was measured followed by a sensitization test 14days later. Experiment 2: rats were tested in the IEN test early adulthood and given five administrations of amphetamine (0.3mg/kg) or saline and then either stayed in or switched housing environments for 30days. Rats were then re-tested in the IEN test in late adulthood and administered five more injections of their respective treatments and tested for locomotor sensitization. Results indicate that IC and SC increased the response to novelty. EC housing decreased locomotor response to amphetamine and saline, and SC housing increased the locomotor response to amphetamine. Mediation results indicated that the late adult novelty response fully mediates the locomotor response to amphetamine and saline, while the early adulthood novelty response did not.
conclusionsDifferential housing changes novelty and amphetamine locomotor response. Novelty response is altered into adulthood and provides evidence that enrichment can be used to reduce drug vulnerability.
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