Evidence map›Paper›PMID 28108025›Full record

ReviewJournal of neuroimmunology2017

Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination.

Carine Savarin, Cornelia C Bergmann

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neuroimmunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Viruses · 2024
    Review
  4. Visual evoked potential abnormalities in patients with COVID-19.Revista da Associacao Medica Brasileira (1992) · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Emerging Roles of Coronavirus in Autoimmune Diseases.Archives of medical research · 2021
    Review
  11. Review
  12. Review
  13. Article
  14. COVID-19: Neuroimaging Features of a Pandemic.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
    Review
  15. Review
  16. Review
  17. Review
  18. Multiple sclerosis following SARS-CoV-2 infection.Multiple sclerosis and related disorders · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carine SavarinLerner Research Institute, Cleveland Clinic, Neuroscience Department NC-30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: savaric@ccf.org.
Cornelia C BergmannLerner Research Institute, Cleveland Clinic, Neuroscience Department NC-30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Cleveland Clinic Lerner College of Medicine · US

Funding

IL-10-dependent regulation of viral-induced demyelinationR01NS091183 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BERGMANN, CORNELIA · 2015 to 2019
$2.0M
Viral suppression of CNS autoimmunityR01NS069690 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BERGMANN, CORNELIA · 2011 to 2015
$1.7M
NINDS NIH HHS R01 NS069690NINDS NIH HHS R01 NS091183
6 · The paper itself

Abstract

Genetic and environmental factors, i.e. infections, have been proposed to contribute to disease induction and relapsing events in multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system (CNS). While research has mainly focused on virus associated autoimmune activation, less is known about prevention of autoimmunity, especially following resolving infections associated with CNS tissue damage. This review discusses novel insights on control of self-reactive (SR) T cells activated during neurotropic coronavirus-induced demyelination. A new concept is introduced that SR T cells can be dampened by distinct regulatory mechanisms in the periphery and the CNS, thereby preventing autoimmune disease.

Indexed as

Demyelinating DiseasesAnimalsAutoimmunityCD4-Positive T-LymphocytesCoronavirusCoronavirus InfectionsHumansLymphocyte ActivationCentral nervous system (CNS)Multiple sclerosisRegulatory T cellsSelf-reactive (SR) CD4 T cellsVirus

Identifiers

PMID28108025
PMCPMC5474352
OpenAlexW2578032255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.