Evidence map›Paper›PMID 28107887›Full record

ArticleJournal of psychosomatic research2017

Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.

Jacob P Feigal, Stephen H Boyle, Zainab Samad, Eric J Velazquez, Jennifer L Wilson, Richard C Becker, Redford B Williams, Cynthia M Kuhn, Thomas L Ortel, Joseph G Rogers and 2 more

Abstract read
In one paragraph

Article in Journal of psychosomatic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Psychological factors of suspect coronary microvascular dysfunction in patients undergoing SPECT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jacob P FeigalDepartment of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC, United States; Department of Medicine, Duke University Medical Center, Durham, NC, United States.
Stephen H BoyleDepartment of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
Zainab SamadDepartment of Medicine, Duke University Medical Center, Durham, NC, United States.
Eric J VelazquezDepartment of Medicine, Duke University Medical Center, Durham, NC, United States.
Jennifer L WilsonDepartment of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
Richard C BeckerDepartment of Medicine, Duke University Medical Center, Durham, NC, United States.
Redford B WilliamsDepartment of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
Cynthia M KuhnDepartment of Pharmacology & Cancer Biology, Duke University, Durham, NC, United States.
Thomas L OrtelDepartment of Medicine, Duke University Medical Center, Durham, NC, United States.
Joseph G RogersDepartment of Medicine, Duke University Medical Center, Durham, NC, United States.
Christopher M O'ConnorDepartment of Medicine, Duke University Medical Center, Durham, NC, United States.
Wei JiangDepartment of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC, United States; Department of Medicine, Duke University Medical Center, Durham, NC, United States. Electronic address: jiang001@mc.duke.edu.
Duke Medical Center · USDuke University Hospital · USDuke University · US

Funding

Responses of Myocardial Ischemia to Sertraline TreatmentR01HL085704 · NHLBI · DUKE UNIVERSITY · PI JIANG, WEI · 2006 to 2011
$2.9M
Biomarkers of Mental Stress Induced Myocardial Ischemia and CHD PrognosisR01HL118077 · NHLBI · DUKE UNIVERSITY · PI JIANG, WEI · 2014 to 2016
$1.9M
NHLBI NIH HHS R01 HL085704NHLBI NIH HHS R01 HL118077
6 · The paper itself

Abstract

objectiveDepressive symptoms have been associated with myocardial ischemia induced by mental (MSIMI) and exercise (ESIMI) stress in clinically stable ischemic heart disease (IHD) patients, but the association between positive emotions and inducible ischemia is less well characterized. The objective of this study was to examine the associations between ratings of well-being and stress-induced ischemia.

methodsSubjects were adult patients with documented IHD underwent mental and exercise stress testing for the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) trial. The General Well-Being Schedule (GWBS), with higher scores reflecting greater subjective well-being, and the Center for Epidemiologic Studies Depression Scale (CES-D) were obtained from the REMIT participants. Echocardiography was used to measure ischemic responses to mental stress and Bruce protocol treadmill exercise testing. Data were analyzed using logistic regression adjusting for age, sex, resting left-ventricular ejection fraction (LVEF), and resting wall motion score index, as well as health-related behaviors.

resultsGWBS scores were obtained for 210 individuals, with MSIMI present in 92 (43.8%) and ESIMI present in 64 (30.5%). There was a significant inverse correlation between GWBS-PE (Positive Emotion subscale) scores and probability of ESIMI (OR=0.55 (95%CI 0.36-0.83), p=0.005). This association persisted after additional control for CESD subscales measuring negative and positive emotions and for variables reflecting health-related behaviors. A similar inverse correlation between GWBS-PE and MSIMI was observed, but did not reach statistical significance (OR=0.81 (95%CI 0.54-1.20), p=0.28).

conclusionThis is, to our knowledge, the first study demonstrating that greater levels of self-reported positive emotions are associated with a lower likelihood of ESIMI among patients with known IHD. Our results highlight the important interface functions of the central nervous and cardiovascular systems and underscore areas for future investigation.

Indexed as

Adaptation, PsychologicalEmotionsExercise TestSurveys and QuestionnairesAdultAgedCohort StudiesEchocardiographyFemaleHumansMaleMiddle AgedMyocardial IschemiaPredictive Value of TestsPsychometricsQuality of LifeCoronary heart diseaseExercise induced ischemiaGeneral well-being scaleGeneral Well-Being ScheduleMental stress induced ischemiaPositive emotions

Identifiers

PMID28107887
PMCPMC6044283
OpenAlexW2559696738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.