Evidence map›Paper›PMID 28107699›Full record

ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2017

Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry.

Jing Yang, Steven G Carmella, Stephen S Hecht

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Mass Spectrometric Quantitation ofChemical research in toxicology · 2022
    Article
  3. Metabolism and DNA Adduct Formation of Tobacco-SpecificInternational journal of molecular sciences · 2022
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jing YangMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Steven G CarmellaMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: hecht002@umn.edu.
University of Minnesota Medical Center · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESR01CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN S HECHT · 1999 to 2026
$7.1M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA081301
6 · The paper itself

Abstract

We have developed a chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry (LC-NSI-HRMS/MS) method to investigate the enantiomeric composition of low parts per trillion amounts of the carcinogen N'-nitrosonornicotine (NNN) in the urine of cigarette smokers and smokeless tobacco users. (S)-NNN is the major enantiomer in tobacco and is more carcinogenic than (R)-NNN in rats, but no data are available on the enantiomeric composition of NNN in humans. The method used [

Indexed as

BiomarkersChromatography, LiquidHumansLinear ModelsNitrosaminesReproducibility of ResultsSmokingStereoisomerismTandem Mass SpectrometryBiomarkersNitrosaminesN'-nitrosonornicotineChiral separationChiral stationary phase liquid chromatography–nanoelectrospray ionization–high resolution tandem mass spectrometryEnantiomeric compositionN'-NitrosonornicotineSmokeless tobacco user’s urineSmoker’s urine

Identifiers

PMID28107699
PMCPMC5296371
OpenAlexW2570482542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.