ArticlePloS one2017
Association of In-Hospital Mortality and Dysglycemia in Septic Patients.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diabetes mellitus and mortality in patients admitted to ICU with sepsis: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Stress-induced hyperglycemia and mortality of non-diabetic patients with sepsis: a meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Under- and overdosing insulin in the hospital: A retrospective cohort study of dose deviation and patient outcomes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Continuous vs. intermittent infusion of corticosteroids in septic shock: a GRADE-based systematic review and meta-analysis.Journal of anesthesia, analgesia and critical care · 2026Review
- Simultaneous assessment of stress hyperglycemia ratio and glucose variability to predict all-cause mortality in sepsis patients across different glucose metabolic states: an observational cohort study with interpretable machine learning approach.International journal of surgery (London, England) · 2026Observational
- Association between stress hyperglycemia ratio and acute kidney injury development in patients with sepsis: a retrospective study.Frontiers in endocrinology · 2025Article
- Combined Analysis of Transcriptome and Mendelian Randomization RevealsJournal of inflammation research · 2025Article
- Effectiveness of Minimally Invasive Hepatectomy in Patients with Early or Intermediate-Stage Hepatocellular Carcinoma: A Multi-Institutional Cohort Study in an Asian Population.Journal of hepatocellular carcinoma · 2025Article
- Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU.Annals of medicine · 2024Article
- Associations of Diabetes and Hyperglycaemia with Extent and Outcomes of Acute Burn Injuries.Biomedicines · 2024Article
- New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.Endocrinology, diabetes & metabolism · 2023Observational
- Early glycaemic variability increases 28-day mortality and prolongs intensive care unit stay in critically ill patients with pneumonia.Annals of medicine · 2022Article
- Discharge status validation of the Chang Gung Research database in Taiwan.Biomedical journal · 2022Observational
- Acute glycemic variability and risk of mortality in patients with sepsis: a meta-analysis.Diabetology & metabolic syndrome · 2022Article
- Impact of diabetes mellitus on outcomes of patients with sepsis: an updated systematic review and meta-analysis.Diabetology & metabolic syndrome · 2022Review
- Glycemic Variability Is Independently Associated With Poor Prognosis in Five Pediatric ICU Centers in Southwest China.Frontiers in nutrition · 2022Article
- The association of diabetes and hyperglycemia with sepsis outcomes: a population-based cohort analysis.Internal and emergency medicine · 2021Article
- Susceptibility for Some Infectious Diseases in Patients With Diabetes: The Key Role of Glycemia.Frontiers in public health · 2021Review
- Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients.PloS one · 2021Article
- Stress Hyperglycemia and Mortality in Subjects With Diabetes and Sepsis.Critical care explorations · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe associations between dysglycemia and mortality in septic patients with and without diabetes are yet to be confirmed. Our aim was to analyze the association of diabetes and sepsis mortality, and to examine how dysglycemia (hyperglycemia, hypoglycemia and glucose variability) affects in-hospital mortality of patients with suspected sepsis in emergency department (ED) and intensive care units.
methodsClinically suspected septic patients admitted to ED were included, and stratified into subgroups according to in-hospital mortality and the presence of diabetes. We analyzed patients' demographics, comorbidities, clinical and laboratory parameters, admission glucose levels and severity of sepsis. Odds ratio of mortality was assessed after adjusting for possible confounders. The correlations of admission glucose and CoV (blood glucose coefficients of variation) and mortality in diabetes and non-diabetes were also tested.
resultsDiabetes was present in 58.3% of the patients. Diabetic patients were older, more likely to have end-stage renal disease and undergoing hemodialysis, but had fewer malignancies, less sepsis severity (lower Mortality in Emergency Department Sepsis Score), less steroid usage in emergency department, and lower in-hospital mortality rate (aOR:0.83, 95% CI 0.65-0.99, p = 0.044). Hyperglycemia at admission (glucose≥200 mg/dL) was associated with higher risks of in-hospital mortality among the non-diabetes patients (OR:1.83 vs. diabetes, 95% CI 1.20-2.80, p = 0.005) with the same elevated glucose levels at admission. In addition, CoV>30% resulted in higher risk of death as well (aOR:1.88 vs. CoV between 10 and 30, 95%CI 1.24-2.86 p = 0.003).
conclusionsThis study indicates that while diabetes mellitus seems to be a protective factor in sepsis patients, hyper- or hypoglycemia status on admission, and increased blood glucose variation during hospital stays, were independently associated with increased odds ratio of mortality.
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