ArticlePloS one2017
Amygdala Atrophy and Its Functional Disconnection with the Cortico-Striatal-Pallidal-Thalamic Circuit in Major Depressive Disorder in Females.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis.EBioMedicine · 2018Pooled it
- Topographic organisation of the claustrum-amygdala-prefrontal circuitry in the common marmoset (Callithrix jacchus).Brain structure & function · 2025Article
- Beta-band power modulation in the human amygdala differentiates between go/no-go responses in an arm-reaching task.Journal of neural engineering · 2024Article
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- Serum alkaline phosphatase was independently associated with depression in patients with cerebrovascular disease.Frontiers in psychiatry · 2023Article
- Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic.Frontiers in psychiatry · 2023Article
- Functional connectivity of the amygdala and the antidepressant and antisuicidal effects of repeated ketamine infusions in major depressive disorder.Frontiers in neuroscience · 2023Article
- Characteristics of brain activation in high-level football players at different stages of decision-making tasks off the ball: an fMRI study.Frontiers in human neuroscience · 2023Article
- Vulnerability of the Neonatal Connectome following Postnatal Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study.Brain sciences · 2022Article
- Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression.Life (Basel, Switzerland) · 2021Article
- Prefrontal Lobe and Posterior Cingulate Cortex Activations in Patients with Major Depressive Disorder by Using Standardized Weighted Low-Resolution Electromagnetic Tomography.Journal of personalized medicine · 2021Article
- Aerobic Exercise Decreases Negative Affect by Modulating Orbitofrontal-Amygdala Connectivity in Adolescents.Life (Basel, Switzerland) · 2021Article
- Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms.Translational psychiatry · 2020Article
- Gamma-band modulation in the human amygdala during reaching movements.Neurosurgical focus · 2020Article
- Altered directed functional connectivity of the right amygdala in depression: high-density EEG study.Scientific reports · 2020Article
- Altered amygdala subregion-related circuits in treatment-naïve post-traumatic stress disorder comorbid with major depressive disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2019Article
- Altered Topology of the Structural Brain Network in Patients With Post-stroke Depression.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder (MDD) is approximately twice as common in females than males. Furthermore, female patients with MDD tend to manifest comorbid anxiety. Few studies have explored the potential anatomical and functional brain changes associated with MDD in females. Therefore, the purpose of the present study was to investigate the anatomical and functional changes underlying MDD in females, especially within the context of comorbid anxiety.
methodsIn this study, we recruited antidepressant-free females with MDD (N = 35) and healthy female controls (HC; N = 23). The severity of depression and anxiety were evaluated by the Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Structural and resting-state functional images were acquired on a Siemens 3.0 Tesla scanner. We compared the structural volumetric differences between patients and HC with voxel-based morphometry (VBM) analyses. Seed-based voxel-wise correlative analyses were used to identify abnormal functional connectivity. Regions with structural deficits showed a significant correlation between gray matter (GM) volume and clinical variables that were selected as seeds. Furthermore, voxel-wise functional connectivity analyses were applied to identify the abnormal connectivity relevant to seed in the MDD group.
resultsDecreased GM volume in patients was observed in the insula, putamen, amygdala, lingual gyrus, and cerebellum. The right amygdala was selected as a seed to perform connectivity analyses, since its GM volume exhibited a significant correlation with the clinical anxiety scores. We detected regions with disrupted connectivity relevant to seed primarily within the cortico-striatal-pallidal-thalamic circuit.
conclusionsAmygdaloid atrophy, as well as decreased functional connectivity between the amygdala and the cortico-striatal-pallidal-thalamic circuit, appears to play a role in female MDD, especially in relation to comorbid anxiety.
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Registered trials
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