ArticlePloS one2017
Factors Moderating the Relationship Between Childhood Trauma and Premorbid Adjustment in First-Episode Schizophrenia.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Exploring the longitudinal course of motor dexterity in first-episode psychosis: a 10-year follow-up.European archives of psychiatry and clinical neuroscience · 2026Article
- The relationship between lifetime trauma exposure and psychosis in a multi-country case-control study in Africa.SSM. Mental health · 2025Article
- Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion.Schizophrenia bulletin · 2024Article
- A culturally congruent approach to trauma symptoms detection in first-episode psychosis.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Two Neuroanatomical Signatures in Schizophrenia: Expression Strengths Over the First 2 Years of Treatment and Their Relationships to Neurodevelopmental Compromise and Antipsychotic Treatment.Schizophrenia bulletin · 2023Article
- Article
- Review
- Associations of premorbid adjustment with type and timing of childhood trauma in first-episode schizophrenia spectrum disorders.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2021Article
- The relationship between childhood trauma and schizophrenia in the Genomics of Schizophrenia in the Xhosa people (SAX) study in South Africa.Psychological medicine · 2020Article
- Childhood Trauma Associated White Matter Abnormalities in First-Episode Schizophrenia.Schizophrenia bulletin · 2019Article
- Association between mitochondrial DNA and cognitive impairment in schizophrenia: study protocol for a Mexican population.Neuropsychiatric disease and treatment · 2019Article
- Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives.Frontiers in neuroscience · 2019Review
- Sensorimotor gating deficits in "two-hit" models of schizophrenia risk factors.Schizophrenia research · 2018Review
- Notes on the Recent History of Neuroscience in Africa.Frontiers in neuroanatomy · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood trauma is a recognised risk factor for schizophrenia. It has been proposed that childhood trauma interferes with normal neurodevelopment, thereby establishing a biological vulnerability to schizophrenia. Poor premorbid adjustment is frequently a precursor to schizophrenia, and may be a manifestation of neurodevelopmental compromise. We investigated the relationship between childhood trauma and premorbid adjustment in 77 patients with first-episode schizophrenia spectrum disorders. We also investigated possible mediating roles for other selected risk factors in the relationship. We found several significant correlations between different trauma types and both social and academic premorbid adjustment from childhood to late adolescence. There were no significant moderating effects for family history of schizophrenia or family history of psychiatric disorder. History of obstetric complications, substance abuse and poor motor coordination weakened some of the associations between childhood trauma and premorbid adjustment, while poor sequencing of motor acts strengthened the association. Our results confirm previous studies indicating an association between childhood trauma and premorbid adjustment. Results indicate a general rather than specific association, apparent with different types of trauma, and affecting both social and academic components of premorbid adjustment across childhood, early and late adolescence. Further, our results suggest a complex interplay of various risk factors, supporting the notion of different pathways to psychosis.
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