Evidence map›Paper›PMID 28107283›Full record

GuidelineJournal of pediatric gastroenterology and nutrition2017

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN).

Miriam B Vos, Stephanie H Abrams, Sarah E Barlow, Sonia Caprio, Stephen R Daniels, Rohit Kohli, Marialena Mouzaki, Pushpa Sathya, Jeffrey B Schwimmer, Shikha S Sundaram and 1 more

4 registry-linked trialsAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 553 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
553citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04671186 nacompletednot on this mapstarted 2020, after this paper: background citation

Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan

TypeinterventionalSponsorNorthwell HealthRan2020 to 2023Enrolled47ConditionsNon-Alcoholic Fatty Liver DiseaseArmsCulturelle (Lactobacillus rhamnosus strain GG), Placebo
NCT05181176 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of Coffee and Tea Consumption on Adolescent Weight Control - a Randomized Clinical Trial

TypeinterventionalSponsorTel-Aviv Sourasky Medical CenterRan2021 to 2023Enrolled63ConditionsBody WeightArmsCoffee, Green tea, Herbal tea (placebo)
NCT06888570 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Childhood Obesity is a Global Health Issue, Especially in Children With Trisomy 21 (T21), Who Face Higher Risks of Non-alcoholic Fatty Liver Disease (NAFLD). Early Detection Using Non-invasive Tools Like Liver Elastography is Key. Evaluating Dietary Patterns With the 24-hour Food Recall and KIDMED Helps Guide Personalized Interventions

Typeobservational_patient_registrySponsorIMDEA FoodRan2025 to 2025Enrolled34ConditionsObesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)ArmsTo evaluate fat liver content in the cases/controls population.
NCT07731360 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Non-Invasive Diagnostic Panel for MASLD in Children With Obesity: Evaluation of a Multiparametric Biomarker Panel and Genetic Risk Score Using LASSO-Regularized Logistic Regression - The PedMASLD-MultiOmics Pilot Study

TypeobservationalSponsorKayseri City HospitalRan2026 to 2027Enrolled180ConditionsMetabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Insulin Resistance SyndromeArmsNon-Invasive Multi-Parameter Diagnostic Panel
3 · Its place in the literature

Who cites it

553 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Guideline
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Article
  17. Article
  18. Review
  19. Adolescent Obesity: A Stepwise Clinical Approach.Indian journal of pediatrics · 2026
    Review
  20. Article

493 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Miriam B Vos*School of Medicine, Emory University †Children's Healthcare of Atlanta, Atlanta, GA ‡Texas Children's Hospital §Baylor College of Medicine, Houston, TX ||School of Medicine, Yale University, New Haven, CT ¶School of Medicine, University of Colorado, Denver #Children's Hospital Colorado, Aurora, CO **Cincinnati Children's Hospital Medical Center ††Department of Pediatrics, University of Cincinnati, Cincinnati, OH ‡‡Hospital for Sick Children §§School of Medicine, University of Toronto, Toronto ||||Janeway Children's Health and Rehabilitation Centre ¶¶Discipline of Pediatrics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada ##School of Medicine, University of California San Diego ***Rady Children's Hospital, San Diego, CA.
Stephanie H Abrams
Sarah E Barlow
Sonia Caprio
Stephen R Daniels
Rohit Kohli
Marialena Mouzaki
Pushpa Sathya
Jeffrey B Schwimmer
Shikha S Sundaram
Stavra A Xanthakos

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 1995 to 2020
$21.8M
Nonalcoholic Steatohepatittis Clinical Research Network (NASH CRN)U01DK061731 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI ARUN J SANYAL · 2002 to 2026
$11.2M
Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Intestinal bacterial metagenome in pediatric NAFLDR01DK088831 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H, WEINSTOCK, GEORGE M · 2012 to 2016
$7.0M
NAFLD Improvement after Bariatric Surgery: The role of bile acid signalingR01DK100314 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KOHLI, ROHIT · 2015 to 2019
$2.3M
The Intestinal Microbiome in Pediatric NAFLDR56DK088831 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2010 to 2010
$361k
A Pilot Study of Losartan in the Treatment of Pediatric NAFLDR03DK096157 · NIDDK · EMORY UNIVERSITY · PI VOS, MIRIAM B. · 2013 to 2014
$151k
STOPNASH MeetingR13DK107243 · NIDDK · EMORY UNIVERSITY · PI VOS, MIRIAM B. · 2015 to 2015
$20k
NCATS NIH HHS UL1 TR001425NIDDK NIH HHS P30 DK048522NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK088831NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01 DK100314NIDDK NIH HHS R03 DK096157NIDDK NIH HHS R13 DK107243NIDDK NIH HHS R56 DK088831NIDDK NIH HHS U01 DK061731NIDDK NIH HHS U01 DK061734
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into the most common liver disease seen in the pediatric population and is a management challenge for general pediatric practitioners, subspecialists, and for health systems. In this guideline, the expert committee on NAFLD reviewed and summarized the available literature, formulating recommendations to guide screening and clinical care of children with NAFLD.

Indexed as

Bariatric SurgeryChildCombined Modality TherapyDiet TherapyExercise TherapyGastrointestinal AgentsHumansIncidenceNon-alcoholic Fatty Liver DiseasePrevalenceRisk FactorsSeverity of Illness IndexUnited StatesGastrointestinal Agents

Identifiers

PMID28107283
PMCPMC5413933

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.