Evidence map›Paper›PMID 28107202›Full record

ArticleOncotarget2017

Correlation of five secretory proteins with the nasopharyngeal carcinoma metastasis and the clinical applications.

Ya Tao, Kun Wang, Zhen Chen, Lu Long, Qiong Wu, Facai Cui, Lepan Zhu, Manlin Xiang, Yuan Jiang, Yunlai Liang and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ya TaoDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kun WangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhen ChenDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lu LongDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiong WuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Facai CuiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lepan ZhuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Manlin XiangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuan JiangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yunlai LiangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shiyang QiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiqiang XiaoThe Higher Educational Key Laboratory for Cancer Proteomics and Translational Medicine of Hunan, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bin YiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our previous study, five different secretory proteins, including GSN, ADAMTSL4, CALR, PPIA and TXN, have been identified to be associated with the nasopharyngeal carcinoma (NPC) metastasis.In this work, the 5 proteins were further investigated. Bioinformatics analysis suggested that they might play an important role in the process of NPC development.Western blotting analysis showed that all of these 5 targets could be secreted into extracellular by both high metastatic NPC 5-8F cells and non-metastatic NPC 6-10B cells. Except for GSN, the expressions of ADAMTSL4, CALR, PPIA and TXN proteins in extracts of the 5-8F and 6-10B cells were significantly different (P < 0.05). Thus, the expressions of these 4 differentially expressed proteins were further tested in a cohort of NPC tissue specimens. The results indicated that the expression levels of ADAMTSL4 and TXN were highly correlated with the lymph node and distant metastasis (P<0.05) in NPC patients. Moreover, Enzyme-linked immunosorbent assay (ELISA) was used to investigate the concentrations of the ADAMTSL4 and TXN in serum specimens of NPC patients. The results revealed that serum ADAMTSL4 expression level was closely correlated with lymph node metastasis and clinical stage (P<0.05) in NPC patients, and it was able to discriminate metastasis NPC from non-metastasis NPC with a sensitivity of 75.6% and a specificity of 64.7%. The present data show for the first time that the ADAMTSL4 and TXN may be novel and potential biomarkers for predicting the NPC metastasis.Furthermore, the serum ADAMTSL4 could be a potential serum tumor biomarker for prognosis of NPC.

Indexed as

Biomarkers, TumorCarcinomaCell Line, TumorFemaleHumansLymphatic MetastasisMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm MetastasisPrognosisBiomarkers, TumorADAMTSL4metastasisnasopharyngeal carcinomasecretory proteinsserum tumor biomarker

Identifiers

PMID28107202
PMCPMC5438738
OpenAlexW2577462344

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.