Evidence map›Paper›PMID 28107095›Full record

ArticleCell cycle (Georgetown, Tex.)2017

Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes.

Victoria Fischer, Michael Wong, Feng-Qian Li, Ken-Ichi Takemaru

Open access · hybridAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Victoria Fischera Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University , Stony Brook , NY , USA.
Michael Wongb Department of Pharmacological Sciences , Stony Brook University , Stony Brook , NY , USA.
Feng-Qian Lia Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University , Stony Brook , NY , USA.
Ken-Ichi Takemarua Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University , Stony Brook , NY , USA.
Stony Brook University · US

Funding

Chibby and Wnt Signaling in Ciliated Cell DifferentiationR01HL107493 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI TAKEMARU, KEN-ICHI · 2011 to 2015
$2.1M
NHLBI NIH HHS R01 HL107493
6 · The paper itself

Abstract

Chibby1 (Cby1) was originally isolated as a binding partner for β-catenin, a dual function protein in cell-cell adhesion and in canonical Wnt signaling. The canonical Wnt/β-catenin pathway is dysregulated in various diseases including cancer, most notably of the gastrointestinal origin. To investigate the role of Cby1 in colorectal tumorigenesis, we generated stable Cby1-knockdown (K

Indexed as

Gene Knockdown Techniquesbeta CateninCadherinsCarrier ProteinsCell Line, TumorCell MembraneCell MovementCell ProliferationCell ShapeEpithelial CellsEpitheliumHEK293 CellsHumansMesodermNuclear ProteinsProtein Transportbeta CateninCadherinsCarrier ProteinsCBY1 protein, humanNuclear Proteinscell-cell adhesionChibbyChibby1colon cancerE-cadherinepithelial-to-mesenchymal transitionmetastasiswntβ-catenin

Identifiers

PMID28107095
PMCPMC5351918
OpenAlexW2573583089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.