Evidence map›Paper›PMID 28106823›Full record

ArticleInternational journal of molecular sciences2017

Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer.

Giulia Bottai, Lixia Diao, Keith A Baggerly, Laura Paladini, Balázs Győrffy, Carlotta Raschioni, Lajos Pusztai, George A Calin, Libero Santarpia

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Giulia BottaiOncology Experimental Therapeutics, Humanitas Clinical and Research Institute, 20089 Rozzano-Milan, Italy. giulia.bottai@humanitasresearch.it.
Lixia DiaoDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ldiao@mdanderson.org.
Keith A BaggerlyDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. kabagger@mdanderson.org.
Laura PaladiniOncology Experimental Therapeutics, Humanitas Clinical and Research Institute, 20089 Rozzano-Milan, Italy. laura.paladini@humanitasresearch.it.
Balázs Győrffy2nd Department of Pediatrics, Semmelweis University, H-1094 Budapest, Hungary. gyorffy.balazs@ttk.mta.hu.
Carlotta RaschioniOncology Experimental Therapeutics, Humanitas Clinical and Research Institute, 20089 Rozzano-Milan, Italy. carlotta.raschioni@humanitas.it.
Lajos PusztaiDepartment of Breast Medical Oncology, Yale University, Yale Cancer Center, New Haven, CT 06520, USA. lajos.pusztai@yale.edu.
George A CalinDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. gcalin@mdanderson.org.
Libero SantarpiaOncology Experimental Therapeutics, Humanitas Clinical and Research Institute, 20089 Rozzano-Milan, Italy. libero.santarpia@humanitasresearch.it.
Humanitas University · ITThe University of Texas MD Anderson Cancer Center · USSemmelweis University · HUYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Protein-coding and non-coding RNA biomarkers for early detection of CLLR01CA182905 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABRUZZO, LYNNE V., CALIN, GEORGE A. · 2014 to 2018
$2.9M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA182905
6 · The paper itself

Abstract

MicroRNAs (miRNAs) simultaneously modulate different oncogenic networks, establishing a dynamic system of gene expression and pathway regulation. In this study, we analyzed global miRNA and messenger RNA (mRNA) expression profiles of 17 cell lines representing different molecular breast cancer subtypes. Spearman's rank correlation test was used to evaluate the correlation between miRNA and mRNA expression. Hierarchical clustering and pathway analysis were also performed. Publicly available gene expression profiles (

Indexed as

TranscriptomeBiomarkers, TumorBreast NeoplasmsCell Line, TumorCluster AnalysisErb-b2 Receptor Tyrosine KinasesFemaleGene Expression Regulation, NeoplasticHumansMesodermMicroRNAsOncostatin MReceptors, EstrogenRNA, MessengerTriple Negative Breast NeoplasmsBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesMicroRNAsOncostatin MReceptors, EstrogenRNA, Messengerbreast cancerimmune responsemicroRNAsmolecular subtypesOncostatin M

Identifiers

PMID28106823
PMCPMC5297825
OpenAlexW2578776792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.