Evidence map›Paper›PMID 28106761›Full record

GuidelineToxins2017

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Michael W Peck, Theresa J Smith, Fabrizio Anniballi, John W Austin, Luca Bano, Marite Bradshaw, Paula Cuervo, Luisa W Cheng, Yagmur Derman, Brigitte G Dorner and 15 more

Abstract readGuidelineHistorical ArticleReview
In one paragraph

Guideline in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Machine learning-based typing ofMicrobiology spectrum · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. The unsung hero:Frontiers in cellular and infection microbiology · 2026
    Article
  14. Identification of botulism C/D in 2 dogsThe Canadian veterinary journal = La revue veterinaire canadienne · 2026
    Article
  15. Probing the properties of PTEN specific botulinum toxin type E mutants.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Michael W PeckInstitute of Food Research, Norwich NR4 7UA, UK. Mike.Peck@ifr.ac.uk.
Theresa J SmithMolecular and Translational Sciences Division, United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. theresa.j.smith.ctr@mail.mil.
Fabrizio AnniballiNational Reference Centre for Botulism, Istituto Superiore di Sanita, Rome 299-00161, Italy. fabrizio.anniballi@iss.it.
John W AustinBureau of Microbial Hazards, Health Canada, Ottawa, ON K1A 0K9, Canada. john.austin@hc-sc.gc.ca.
Luca BanoIstituto Zooprofilattico Sperimentale delle Venezie, Treviso 31020, Italy. lbano@izsvenezie.it.
Marite BradshawDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706, USA. mbradsha@wisc.edu.
Paula CuervoÁrea de Microbiología, Departamento de Patología, Universidad Nacional de Cuyo, Mendoza 450001, Argentina. paulacuervo84@gmail.com.
Luisa W ChengFoodborne Toxin Detection and Prevention Research Unit, Western Regional Research Center, U.S. Department of Agriculture, Albany, CA 94710, USA. luisa.cheng@ars.usda.gov.
Yagmur DermanDepartment of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki 00014, Finland. yagmur.derman@helsinki.fi.
Brigitte G DornerRobert Koch Institute, Berlin 13353, Germany. dornerb@rki.de.
Audrey FisherApplied Physics Laboratory, Johns Hopkins University, Baltimore, MD 21218, USA. audrey.fischer@jhuapl.edu.
Karen K HillLos Alamos National Laboratories, Los Alamos, NM 87545, USA. khill@lanl.gov.
Suzanne R KalbNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. skalb@cdc.gov.
Hannu KorkealaDepartment of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki 00014, Finland. hannu.korkeala@helsinki.fi.
Miia LindströmDepartment of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki 00014, Finland. miia.lindstrom@helsinki.fi.
Florigio ListaArmy Medical and Veterinary Research Center, Rome 00184, Italy. romano.lista@gmail.com.
Carolina LúquezNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA. cluquez@cdc.gov.
Christelle MazuetInstitut Pasteur, Bactéries anaérobies et Toxines, Paris 75015, France. christelle.mazuet@pasteur.fr.
Marco PirazziniBiomedical Sciences Department, University of Padova, Padova 35131, Italy. marcopiraz@gmail.com.
Michel R PopoffInstitut Pasteur, Bactéries anaérobies et Toxines, Paris 75015, France. mpopoff@pasteur.fr.
Ornella RossettoBiomedical Sciences Department, University of Padova, Padova 35131, Italy. ornella.rossetto@unipd.it.
Andreas RummelInstitut für Toxikologie, Medizinische Hochschule Hannover, Hannover 30623, Germany. Rummel.Andreas@mh-hannover.de.
Dorothea SesardicNational Institute for Biological Standards and Control, a Centre of Medicines and Healthcare Products Regulatory Agency, Hertfordshire EN6 3QG, UK. thea.sesardic@nibsc.org.
Bal Ram SinghBotulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA. bsingh@inads.org.
Sandra C StringerInstitute of Food Research, Norwich NR4 7UA, UK. Sandra.Stringer@ifr.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/J004529/1
6 · The paper itself

Abstract

Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.

Indexed as

Terminology as TopicBotulinum ToxinsConsensusHistory, 20th CenturyHistory, 21st CenturyHumansBotulinum ToxinsbotulinumbotulismClostridium botulinumguidelinesneurotoxinsnomenclaturesubtypes

Identifiers

PMID28106761
PMCPMC5308270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.