Evidence map›Paper›PMID 28106743›Full record

ArticleInternational journal of molecular sciences2017

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors.

Anca Stana, Dan C Vodnar, Radu Tamaian, Adrian Pîrnău, Laurian Vlase, Ioana Ionuț, Ovidiu Oniga, Brînduşa Tiperciuc

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Isolation and Characterization of an Endophytic FungusFrontiers in bioengineering and biotechnology · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Antimicrobial Effect ofPharmaceutics · 2019
    Article
  15. Article
  16. A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects andOxidative medicine and cellular longevity · 2019
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anca StanaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. teodora_anca@yahoo.com.
Dan C VodnarDepartment of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Manăştur Street, RO-400372 Cluj-Napoca, Romania. dan.vodnar@usamvcluj.ro.
Radu TamaianNational Institute for Research and Development for Cryogenic and Isotopic Technologies, 4th Uzinei Street, RO-240050 Râmnicu Vâlcea, Romania. radu.tamaian@icsi.ro.
Adrian PîrnăuNational Institute for Research and Development of Isotopic and Molecular Technologies, RO-400293 Cluj-Napoca, Romania. adrian.pirnau@itim-cj.ro.
Laurian VlaseDepartment of Pharmaceutical Technology and Biopharmaceutics, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. vlaselaur@yahoo.com.
Ioana IonuțDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. ionut.ioana@umfcluj.ro.
Ovidiu OnigaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. onigao65@yahoo.com.
Brînduşa TiperciucDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. brandu32@yahoo.com.
Iuliu Hațieganu University of Medicine and Pharmacy · RONational Institute for Research and Development of Isotopic and Molecular Technologies · ROUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twenty-three thiazolin-4-ones were synthesized starting from phenylthioamide or thiourea derivatives by condensation with α-monochloroacetic acid or ethyl α-bromoacetate, followed by substitution in position 5 with various arylidene moieties. All the synthesized compounds were physico-chemically characterized and the IR (infrared spectra), ¹H NMR (proton nuclear magnetic resonance),

Indexed as

Drug Design14-alpha Demethylase InhibitorsAntifungal AgentsCandidaFungal ProteinsMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsModels, ChemicalMolecular Docking SimulationMolecular StructureProtein BindingProtein DomainsSpectrophotometry, InfraredSterol 14-DemethylaseThiazoles14-alpha Demethylase InhibitorsAntifungal AgentsFungal ProteinsSterol 14-DemethylaseThiazolesADME-Tox predictorsantifungal activitylanosterol 14α-demethylaselipophilicitymolecular dockingthiazolin-4-one

Identifiers

PMID28106743
PMCPMC5297809
OpenAlexW2578038880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.