ReviewGenes2017
Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies.
Review in Genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05432739 (Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.Scientific reports · 2017Pooled it
- High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology of Lung Cancer Consortium.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Article
- Unique clinical features and transcriptomic profiling of carcinogenesis in patients with familial lung cancer in Yunnan Province, Wumeng mountains, China.Respiratory research · 2026Article
- KIR-HLA gene diversities and susceptibility to lung cancer.Scientific reports · 2022Article
- Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy.Frontiers in immunology · 2022Review
- A Multi-Omics Study of Familial Lung Cancer: Microbiome and Host Gene Expression Patterns.Frontiers in immunology · 2022Article
- Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees.BMC cancer · 2020Article
- COPD-dependent effects of genetic variation in key inflammation pathway genes on lung cancer risk.International journal of cancer · 2020Article
- Lung cancer and family-centered concerns.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Inherited lung cancer: a review.Ecancermedicalscience · 2020Review
- Article
- Lung cancer family history and exposure to occupational/domestic coal combustion contribute to variations in clinicopathologic features and gene fusion patterns in non-small cell lung cancer.Thoracic cancer · 2019Article
- Genome-wide association study of familial lung cancer.Carcinogenesis · 2018Article
- Lung cancer health disparities.Carcinogenesis · 2018Review
- Characteristics of Familial Lung Cancer in Yunnan-Guizhou Plateau of China.Frontiers in oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23-25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.