Evidence map›Paper›PMID 28106253›Full record

ArticleImmunology2017

Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome.

Marina García, Ayelén Iglesias, Verónica I Landoni, Carla Bellomo, Agostina Bruno, María Teresa Córdoba, Luciana Balboa, Gabriela C Fernández, María Del Carmen Sasiain, Valeria P Martínez and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Andes Virus: From Transmission Dynamics to Pandemic Potential.European journal of clinical investigation · 2026
    Review
  2. Review
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  6. Low-doseFrontiers in immunology · 2024
    Article
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  9. Review
  10. Article
  11. Article
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  15. Generation of plasma cells and CD27Clinical & translational immunology · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Marina GarcíaLaboratorio de Inmunología de Enfermedades Respiratorias, Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina (ANM), Ciudad autónoma de Buenos Aires, Argentina.ORCID 0000-0002-9130-3933
Ayelén IglesiasLaboratorio Nacional de Referencia para Hantavirus, Servicio de Biología Molecular, Instituto Nacional de Enfermedades Infecciosas, ANLIS -'Dr. Carlos G. Malbrán', Ciudad autónoma de Buenos Aires, Argentina.
Verónica I LandoniLaboratorio de Fisiología de procesos Inflamatorios, IMEX-CONICET-ANM, Ciudad autónoma de Buenos Aires, Argentina.
Carla BellomoLaboratorio Nacional de Referencia para Hantavirus, Servicio de Biología Molecular, Instituto Nacional de Enfermedades Infecciosas, ANLIS -'Dr. Carlos G. Malbrán', Ciudad autónoma de Buenos Aires, Argentina.
Agostina BrunoLaboratorio de Enfermedades Tropicales, Hospital San Vicente de Paúl, Orán, Salta, Argentina.
María Teresa CórdobaLaboratorio de Enfermedades Tropicales, Hospital San Vicente de Paúl, Orán, Salta, Argentina.
Luciana BalboaLaboratorio de Inmunología de Enfermedades Respiratorias, Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina (ANM), Ciudad autónoma de Buenos Aires, Argentina.
Gabriela C FernándezLaboratorio de Fisiología de procesos Inflamatorios, IMEX-CONICET-ANM, Ciudad autónoma de Buenos Aires, Argentina.
María Del Carmen SasiainLaboratorio de Inmunología de Enfermedades Respiratorias, Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina (ANM), Ciudad autónoma de Buenos Aires, Argentina.
Valeria P MartínezLaboratorio Nacional de Referencia para Hantavirus, Servicio de Biología Molecular, Instituto Nacional de Enfermedades Infecciosas, ANLIS -'Dr. Carlos G. Malbrán', Ciudad autónoma de Buenos Aires, Argentina.
Pablo SchierlohLaboratorio de Inmunología de Enfermedades Respiratorias, Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina (ANM), Ciudad autónoma de Buenos Aires, Argentina.
Academia Nacional de Medicina · ARAdministración Nacional de Laboratorios e Institutos de Salud · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beside its key diagnostic value, the humoral immune response is thought to play a protective role in hantavirus pulmonary syndrome. However, little is known about the cell source of these antibodies during ongoing human infection. Herein we characterized B-cell subsets circulating in Andes-virus-infected patients. A notable potent plasmablast (PB) response that increased 100-fold over the baseline levels was observed around 1 week after the onset of symptoms. These PB present a CD3

Indexed as

Acute DiseaseAdultAntibodies, ViralAntigens, CDAutoantigensBiomarkersB-Lymphocyte SubsetsCell ProliferationFemaleHantavirus Pulmonary SyndromeHumansImmunoglobulin ALymphocyte ActivationMaleMiddle AgedOrthohantavirusAntibodies, ViralAntigens, CDAutoantigensBiomarkersImmunoglobulin AAndes virusB cellhantavirus pulmonary syndromeplasmablastpolyclonal activation

Identifiers

PMID28106253
PMCPMC5382343
OpenAlexW2574344175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.