ArticleScientific reports2017
Complete-genome sequencing elucidates outbreak dynamics of CA-MRSA USA300 (ST8-spa t008) in an academic hospital of Paramaribo, Republic of Suriname.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed.
- Molecular typing of PVL-positive Staphylococcus aureus isolates from Lithuania and genome sequencing of a local outbreak strain.Scientific reports · 2026Article
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- Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities.Nature communications · 2025Article
- Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities.medRxiv : the preprint server for health sciences · 2025Article
- Comparative genome analyses of Staphylococcus aureus from platelet concentrates reveal rearrangements involving loss of type VII secretion genes.Access microbiology · 2024Article
- Comparison of genomic diversity between single and pooledMicrobial genomics · 2023Article
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- The Plasmidomic Landscape of Clinical Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- A pseudo-outbreak of MRSA due to laboratory contamination related to MRSA carriage of a laboratory staff member.Antimicrobial resistance and infection control · 2023Article
- Novel insights into the role of the mobilome in ecological diversification and success ofMicrobial genomics · 2022Article
- Common Adaptive Strategies Underlie Within-Host Evolution of Bacterial Pathogens.Molecular biology and evolution · 2021Article
- Genomic analysis revealed a novel genotype of methicillin-susceptible Staphylococcus aureus isolated from a fatal sepsis case in dengue patient.Scientific reports · 2021Article
- Whole Genome Sequencing Provides an Added Value to the Investigation of Staphylococcal Food Poisoning Outbreaks.Frontiers in microbiology · 2021Article
- Serotyping, MLST, and Core Genome MLST Analysis ofFrontiers in microbiology · 2021Article
- Genomic and Proteomic Characterization of the Extended-Spectrum β-Lactamase (ESBL)-ProducingMicroorganisms · 2020Article
- Nanopore sequencing reveals genomic map of CTX-M-type extended-spectrum β-lactamases carried by Escherichia coli strains isolated from blue mussels (Mytilus edulis) in Norway.BMC microbiology · 2020Article
- BacPipe: A Rapid, User-Friendly Whole-Genome Sequencing Pipeline for Clinical Diagnostic Bacteriology.iScience · 2020Article
- Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistantProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Livestock-Associated Methicillin-ResistantFrontiers in microbiology · 2019Review
- USA300 Staphylococcus aureus persists on multiple body sites following an infection.BMC microbiology · 2018Article
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7 authors.
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Abstract
We report the investigation of an outbreak situation of methicillin-resistant Staphylococcus aureus (MRSA) that occurred at the Academic Hospital Paramaribo (AZP) in the Republic of Suriname from April to May 2013. We performed whole genome sequencing with complete gap closure for chromosomes and plasmids on all isolates. The outbreak involved 12 patients and 1 healthcare worker/nurse at the AZP. In total 24 isolates were investigated. spa typing, genome-wide single nucleotide polymorphism (SNP) analysis, ad hoc whole genome multilocus sequence typing (wgMLST), stable core genome MLST (cgMLST) and in silico PFGE were used to determine phylogenetic relatedness and to identify transmission. Whole-genome sequencing (WGS) showed that all isolates were members of genomic variants of the North American USA300 clone. However, WGS revealed a heterogeneous population structure of USA300 circulating at the AZP. We observed up to 8 SNPs or up to 5 alleles of difference by wgMLST when the isolates were recovered from different body sites of the same patient or if direct transmission between patients was most likely. This work describes the usefulness of complete genome sequencing of bacterial chromosomes and plasmids providing an unprecedented level of detail during outbreak investigations not being visible by using conventional typing methods.
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