ArticleScientific reports2017
Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 66 citations in OpenAlex.
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- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
- Cell targeting by the bicomponent leukocidin subunit HlgB drives Staphylococcus aureus pathophysiology.The Journal of biological chemistry · 2025Article
- Rapid Detection of Panton-Valentine Leukocidin Production in Clinical Isolates ofPathogens (Basel, Switzerland) · 2025Article
- Characterisation ofToxins · 2025Article
- Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025Article
- Bacteriophage-driven emergence and expansion of Staphylococcus aureus in rodent populations.PLoS pathogens · 2024Article
- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- Molecular Characteristics and Pathogenicity ofInternational journal of molecular sciences · 2023Review
- Virulence Mechanisms of Staphylococcal Animal Pathogens.International journal of molecular sciences · 2023Review
- Absence of Staphylococcus aureus in Wild Populations of Fish Supports a Spillover Hypothesis.Microbiology spectrum · 2023Article
- Characterisation of aPathogens (Basel, Switzerland) · 2023Article
- Prophage-encoded immune evasion factors are critical forCell genomics · 2022Article
- Sequence Analysis of NovelInternational journal of molecular sciences · 2022Article
- MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework.Frontiers in microbiology · 2022Review
- Staphylococcus aureus isolates from Eurasian Beavers (Castor fiber) carry a novel phage-borne bicomponent leukocidin related to the Panton-Valentine leukocidin.Scientific reports · 2021Article
- Detection ofArchives of Razi Institute · 2021Article
- First Report of Antimicrobial Susceptibility and Virulence Gene Characterization Associated withAnimals : an open access journal from MDPI · 2021Article
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Authors and funding
34 authors at 18 institutions in 8 countries.
Funding
Abstract
Bicomponent pore-forming leukocidins are a family of potent toxins secreted by Staphylococcus aureus, which target white blood cells preferentially and consist of an S- and an F-component. The S-component recognizes a receptor on the host cell, enabling high-affinity binding to the cell surface, after which the toxins form a pore that penetrates the cell lipid bilayer. Until now, six different leukocidins have been described, some of which are host and cell specific. Here, we identify and characterise a novel S. aureus leukocidin; LukPQ. LukPQ is encoded on a 45 kb prophage (ΦSaeq1) found in six different clonal lineages, almost exclusively in strains cultured from equids. We show that LukPQ is a potent and specific killer of equine neutrophils and identify equine-CXCRA and CXCR2 as its target receptors. Although the S-component (LukP) is highly similar to the S-component of LukED, the species specificity of LukPQ and LukED differs. By forming non-canonical toxin pairs, we identify that the F-component contributes to the observed host tropism of LukPQ, thereby challenging the current paradigm that leukocidin specificity is driven solely by the S-component.
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