Evidence map›Paper›PMID 28106051›Full record

ArticleScientific reports2017

Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury.

Damir Nizamutdinov, Sharon DeMorrow, Matthew McMillin, Jessica Kain, Sanjib Mukherjee, Suzanne Zeitouni, Gabriel Frampton, Paul Clint S Bricker, Jacob Hurst, Lee A Shapiro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Damir NizamutdinovDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Sharon DeMorrowDepartent of Internal Medicine, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Matthew McMillinDepartent of Internal Medicine, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Jessica KainDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Sanjib MukherjeeDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Suzanne ZeitouniDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Gabriel FramptonDepartent of Internal Medicine, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Paul Clint S BrickerDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Jacob HurstDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Lee A ShapiroDepartment of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, Texas, 76504, USA.
Temple College · USTexas A&M University · USCentral Texas Veterans Health Care System · US

Funding

BLRD VA IK2 BX003486
6 · The paper itself

Abstract

Annually, there are over 2 million incidents of traumatic brain injury (TBI) and treatment options are non-existent. While many TBI studies have focused on the brain, peripheral contributions involving the digestive and immune systems are emerging as factors involved in the various symptomology associated with TBI. We hypothesized that TBI would alter hepatic function, including bile acid system machinery in the liver and brain. The results show activation of the hepatic acute phase response by 2 hours after TBI, hepatic inflammation by 6 hours after TBI and a decrease in hepatic transcription factors, Gli 1, Gli 2, Gli 3 at 2 and 24 hrs after TBI. Bile acid receptors and transporters were decreased as early as 2 hrs after TBI until at least 24 hrs after TBI. Quantification of bile acid transporter, ASBT-expressing neurons in the hypothalamus, revealed a significant decrease following TBI. These results are the first to show such changes following a TBI, and are compatible with previous studies of the bile acid system in stroke models. The data support the emerging idea of a systemic influence to neurological disorders and point to the need for future studies to better define specific mechanisms of action.

Indexed as

Acute-Phase ReactionAnimalsBrain Injuries, TraumaticCarrier ProteinsDisease Models, AnimalHypothalamusLiverMembrane GlycoproteinsMice, Inbred C57BLNeuronsTime Factorsbile acid binding proteinsCarrier ProteinsMembrane Glycoproteins

Identifiers

PMID28106051
PMCPMC5247752
OpenAlexW2572645763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.