ArticleNature communications2017
Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 453 citations in OpenAlex.
- Roles of K-channel activity in feather bud morphogenesis.Developmental biology · 2026Article
- Novel tissue mechanics-guided cellular flows drive the formation of feather follicles.The EMBO journal · 2026Article
- Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation.Scientific reports · 2025Article
- Medulla-free barb rami highlight the morphological diversity of early feathers.Zoological research · 2025Article
- Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth.Developmental biology · 2025Review
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Skin regional specification and higher-orderScience advances · 2025Article
- The origin and early evolution of feathers: implications, uncertainties and future prospects.Biology letters · 2025Review
- Review
- A chromosome-level genome assembly of the Asian house martin implies potential genes associated with the feathered-foot trait.G3 (Bethesda, Md.) · 2024Article
- Conserved regulatory switches for the transition from natal down to juvenile feather in birds.Nature communications · 2024Article
- Functional constraints on the number and shape of flight feathers.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm.Chinese journal of physics · 2023Article
- Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves.Research square · 2023Article
- Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles.Health science reports · 2022Article
- Cyclic growth of dermal papilla and regeneration of follicular mesenchymal components during feather cycling.Development (Cambridge, England) · 2021Article
- Making region-specific integumentary organs in birds: evolution and modifications.Current opinion in genetics & development · 2021Review
- Transcriptome Comparison Reveals Key Components of Nuptial Plumage Coloration in Crested Ibis.Biomolecules · 2020Article
- Cassowary gloss and a novel form of structural color in birds.Science advances · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Adaptation of feathered dinosaurs and Mesozoic birds to new ecological niches was potentiated by rapid diversification of feather vane shapes. The molecular mechanism driving this spectacular process remains unclear. Here, through morphology analysis, transcriptome profiling, functional perturbations and mathematical simulations, we find that mesenchyme-derived GDF10 and GREM1 are major controllers for the topologies of rachidial and barb generative zones (setting vane boundaries), respectively, by tuning the periodic-branching programme of epithelial progenitors. Their interactions with the anterior-posterior WNT gradient establish the bilateral-symmetric vane configuration. Additionally, combinatory effects of CYP26B1, CRABP1 and RALDH3 establish dynamic retinoic acid (RA) landscapes in feather mesenchyme, which modulate GREM1 expression and epithelial cell shapes. Incremental changes of RA gradient slopes establish a continuum of asymmetric flight feathers along the wing, while switch-like modulation of RA signalling confers distinct vane shapes between feather tracts. Therefore, the co-option of anisotropic signalling modules introduced new dimensions of feather shape diversification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.