Evidence map›Paper›PMID 28105727›Full record

ArticleMolecular nutrition & food research2017

Placental dysfunction is associated with altered microRNA expression in pregnant women with low folate status.

Bernadette C Baker, Fiona L Mackie, Samantha C Lean, Susan L Greenwood, Alexander E P Heazell, Karen Forbes, Rebecca L Jones

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  4. The role of microRNAs in pregnancies complicated by maternal diabetes.Clinical science (London, England : 1979) · 2024
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  12. Interaction between Metformin, Folate and Vitamin BInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bernadette C BakerMaternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.
Fiona L MackieCentre of Women's and Newborn's Health & Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Samantha C LeanMaternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.
Susan L GreenwoodMaternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.
Alexander E P HeazellMaternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.
Karen ForbesDivision of Reproduction and Early Development, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Rebecca L JonesMaternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.
University of Manchester · GBUniversity of Birmingham · GBUniversity of Leeds · GB

Funding

Wellcome TrustWellcome Trust 097820/Z/11/B
6 · The paper itself

Abstract

scopeLow maternal folate status during pregnancy increases the risk of delivering small for gestational age (SGA) infants, but the mechanistic link between maternal folate status, SGA, and placental dysfunction is unknown. microRNAs (miRNAs) are altered in pregnancy pathologies and by folate in other systems. We hypothesized that low maternal folate status causes placental dysfunction, mediated by altered miRNA expression. METHODS AND

resultsA prospective observational study recruited pregnant adolescents and assessed third trimester folate status and placental function. miRNA array, QPCR, and bioinformatics identified placental miRNAs and target genes. Low maternal folate status is associated with higher incidence of SGA infants (28% versus 13%, p < 0.05) and placental dysfunction, including elevated trophoblast proliferation and apoptosis (p < 0.001), reduced amino acid transport (p < 0.01), and altered placental hormones (pregnancy-associated plasma protein A, progesterone, and human placental lactogen). miR-222-3p, miR-141-3p, and miR-34b-5p were upregulated by low folate status (p < 0.05). Bioinformatics predicted a gene network regulating cell turnover. Quantitative PCR demonstrated that key genes in this network (zinc finger E-box binding homeobox 2, v-myc myelocytomatosis viral oncogene homolog (avian), and cyclin-dependent kinase 6) were reduced (p < 0.05) in placentas with low maternal folate status.

conclusionThis study supports that placental dysfunction contributes to impaired fetal growth in women with low folate status and suggests altered placental expression of folate-sensitive miRNAs and target genes as a mechanistic link.

Indexed as

AdolescentCyclin-Dependent Kinase 6FemaleFolic Acid DeficiencyGene Expression Regulation, DevelopmentalHumansInfant, NewbornInfant, Small for Gestational AgeMaternal Nutritional Physiological PhenomenaMicroRNAsPlacentaPregnancyPregnancy OutcomePregnancy Trimester, ThirdCDK6 protein, humanCyclin-Dependent Kinase 6MicroRNAsfetal growthfolate deficiencygene expressionmicroRNAplacental dysfunction

Identifiers

PMID28105727
PMCPMC5573923
OpenAlexW2573862840

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.