ArticleClinical genetics2017
Association of genetic variation with blood pressure traits among East Africans.
Article in Clinical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Effect of Dietary Salt Excess on DNA Methylation and Transcriptional Regulation of Human Angiotensinogen Gene Expression.American journal of hypertension · 2026Article
- ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Review
- Prevalence of IGFBP3, NOS3 and TCF7L2 polymorphisms and their association with hypertension: a population-based study with Brazilian women of African descent.BMC research notes · 2021Article
- Review
- A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits.G3 (Bethesda, Md.) · 2020Article
- A genome-wide association and replication study of blood pressure in Ugandan early adolescents.Molecular genetics & genomic medicine · 2019Article
- A polymorphism in intron I of the human angiotensinogen gene (The Journal of biological chemistry · 2019Article
- Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.The pharmacogenomics journal · 2019Review
- Transethnic and race-stratified genome-wide association study of fibroid characteristics in African American and European American women.Fertility and sterility · 2018Article
- Association study ofOncotarget · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionGenetic variation may play explain some of the disparity in prevalence and control of hypertension across Sub-Saharan Africa. However, there have been very few studies to characterize genetic variation of blood pressure traits.
aimTo determine whether a set of blood pressure-associated genetic loci can be replicated among samples East African samples.
methodsTwenty-seven blood pressures (BP)-related single nucleotide polymorphisms (SNPs) were genotyped among 2881 samples from participants in the Medical Education Partnership Initiative for Cardiovascular Disease (MEPI-CVD) survey. Associations with known BP variants were evaluated for systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) as continuous variables and for hypertension (HTN) as a binary variable.
resultsEleven SNPS were associated with at least 1 BP trait (P < .05). Four SNPs; rs2004776, rs7726475, rs11837544 and rs2681492, whose nearest genes are AGT, NPR3/SUB1, PLXNC1 and ATP2B1, respectively, were associated with SBP. Six SNPs, rs2004776, rs11977526, rs11191548, rs381815, rs2681492 and rs1327235, close to AGT, IGFBP3, CYP17A1, PLEKHA7, ATP2B1 and JAG, respectively, were associated with DBP while 2 SNPs located within AGT and IGFBP-3 genes associated with HTN. For PP, 4 variants rs1458038, rs11725861, rs7726475 and rs11953630 whose corresponding genes are FGF5, CHIC2, SUB1/NPR3 and EBF1 reached significance (P < .05). Eight SNPs were replicated in the same effect direction as the parent studies. Risk scores defined using published effect sizes were significantly associated with both SBP (P = .0026) and DBP (P = .0214).
conclusionThe replication of multiple BP variants among East Africans suggests that these variants may have universal effects across ethnic populations.
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