Evidence map›Paper›PMID 28105598›Full record

ReviewClinical pharmacokinetics2017

Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine.

Maud A S Weerink, Michel M R F Struys, Laura N Hannivoort, Clemens R M Barends, Anthony R Absalom, Pieter Colin

14 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical pharmacokinetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 14 registered trials, which are not on this map. Cited by 597 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
597citing papers in PubMed, 18 pooled it
70.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04608331 phase4completednot on this mapstarted 2021, after this paper: background citation

Impact of Dexmedetomidine Supplemented Analgesia on Sleep Quality in Patients at High-risk of Obstructive Sleep Apnea After Major Surgery: A Randomized, Double-blind, and Placebo-controlled Pilot Study

TypeinterventionalSponsorPeking University First HospitalRan2021 to 2022Enrolled152ConditionsObstructive Sleep Apnea, Analgesia, Dexmedetomidine, High-flow Nasal CannulaArmsDexmedetomidine, Placebo
NCT04820101 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Dexmedetomidine for LISA Procedure in Preterm Infants: a Pilot Study

TypeinterventionalSponsorUniversity of PadovaRan2021 to 2023Enrolled40ConditionsRDSArmsDexmedetomidine
NCT05003102 phase4withdrawnnot on this mapstarted 2023, after this paper: background citation

Dexmedetomidine Cycling and Sleep in the Pediatric ICU

TypeinterventionalSponsorVanderbilt University Medical CenterRan2023 to 2023Enrolled0ConditionsCritical Illness, Sedation Complication, DeliriumArmsDexmedetomidine Hydrochloride - Cycling, Fentanyl - PICU Standard, Dexmedetomidine Hydrochloride - PICU Standard
NCT05175781 nacompletednot on this mapstarted 2022, after this paper: background citation

Dexmedetomidine Versus Ketamine to Facilitate Non-invasive Ventilation After Blunt Chest Trauma

TypeinterventionalSponsorAswan University HospitalRan2022 to 2022Enrolled45ConditionsChest TraumaArmsDexmedetomidine Hydrochloride, Ketamine Hydrochloride, Placebo
NCT05567523 phase4completednot on this mapstarted 2019, after this paper: background citation

Effects of Dexmedetomidine at Different Doses on Hemodynamics and Recovery Quality in Elderly Patients Undergoing Hip Replacement Surgery Under General Anesthesia

TypeinterventionalSponsorZhenjiang First People's HospitalRan2019 to 2022Enrolled200ConditionsHip Fractures, Hip DiseaseArmsDexmedetomidine, Normal saline, Midazolam
NCT05619627 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Utility of Oral Dexmedetomidine as the Sole Sedative Agent in Pediatric Population Undergoing MRI

TypeinterventionalSponsorSoroush MerchantRan2026 to 2028Enrolled18ConditionsAnesthesiaArmsDexmedetomidine, General Anesthesia (control group)
NCT06096181 phase2terminatednot on this mapstarted 2023, after this paper: background citation

A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2023 to 2024Enrolled13ConditionsAdolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, RemifentanilArmsRemifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
NCT06468436 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Dexmedetomidine-Esketamine Combination for Sedation and Analgesia on Delirium in ICU Patients With Mechanical Ventilation: A Multicenter Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2030Enrolled1,508ConditionsAged, Intensive Care Units, Ventilators, Mechanical, DexmedetomidineArmsDexmedetomidine-Esketamine Combination, Dexmedetomidine
NCT07151716 phase4completednot on this mapstarted 2025, after this paper: background citation

Effect of Sedation With Dexmedetomidine-esketamine Combination on Delirium in Postoperative ICU Patients: a Randomized Controlled Pilot Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled100ConditionsOlder Patients, Postoperative Care, Intensive Care Unit, DexmedetomidineArmsDexmedetomidine, Dexmedetomidine-esketamine combination
NCT07406555 phase4completednot on this mapstarted 2025, after this paper: background citation

Differences in C-Reactive Protein Levels Between Traumatic Brain Injury Patients Receiving Dexmedetomidine and Those Not Receiving Dexmedetomidine Undergoing Craniotomy at Prof. Dr. Margono Soekarjo Regional General Hospital, Purwokerto

TypeinterventionalSponsorUniversitas Jenderal SoedirmanRan2025 to 2025Enrolled25ConditionsTraumatic Brain InjuryArmsDexmedetomidine, Sufentanyl
NCT07576517 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2030Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07576543 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2031Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07610343 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Intranasal Dexmedetomidine-esketamine on Sleep Quality and Cognitive Function in Older Adults With Mild-to-moderate Cognitive Impairment: a Randomized, Double-blind, and Placebo-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled60ConditionsOlder Adults, Cognitive Impairment, Sleep Disorders, DexmedetomidineArmsDexmedetomidine-esketamine combination, Placebo
NCT07639099 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Intranasal Esketamine-dexmedetomidine Combination on Postpartum Depression in Parturients With Prenatal Depressive Symptoms: a Randomized, Double-blind, and Placebo-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2029Enrolled164ConditionsParturients, Depressive Symptoms, Esketamine, DexmedetomidineArmsEsketamine-dexmedetomidine combination, Placebo
3 · Its place in the literature

Who cites it

597 citing papers in PubMed, 18 syntheses or guidelines pooled it, 1,147 citations in OpenAlex.

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  4. Antianxiety effects of dexmedetomidine: systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026
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  9. Dexmedetomidine Mitigates Sevoflurane-Induced Neurodevelopmental Effects in Paediatric Anaesthesia: A Meta-Analysis and Preclinical Study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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537 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Maud A S WeerinkDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
Michel M R F StruysDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands. m.m.r.f.struys@umcg.nl.
Laura N HannivoortDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
Clemens R M BarendsDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
Anthony R AbsalomDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
Pieter ColinDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexmedetomidine is an α

Indexed as

Administration, BuccalAdministration, IntranasalAdrenergic alpha-2 Receptor AgonistsAdultAnalgesics, Non-NarcoticAnesthesiaBody Mass IndexBradycardiaCardiac OutputDexmedetomidineFemaleHemodynamicsHumansHypertensionHypnotics and SedativesHypotensionAdrenergic alpha-2 Receptor AgonistsAnalgesics, Non-NarcoticDexmedetomidineHypnotics and SedativesReceptors, GABASerum Albumin, Human

Identifiers

PMID28105598
PMCPMC5511603
OpenAlexW2576234460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 8 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.