ArticleClinical and experimental medicine2017
Spatial distribution of mast cells around vessels and glands in human gastric carcinoma.
Article in Clinical and experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- AllergoOncology: Emerging Translational and Clinical Significance of Basophils and Mast Cells in Cancer.Clinical and translational allergy · 2026Review
- Gastric Cancer-Derived Exosomes Activate Mast Cells via the SCF/c-KIT Pathway to Drive Angiogenesis and Metastasis.Oncology research · 2026Article
- Tryptase and tumor angiogenesis.Frontiers in oncology · 2024Review
- New insights into the role of mast cells as a therapeutic target in cancer through the blockade of immune checkpoint inhibitors.Frontiers in medicine · 2024Review
- The regulatory role and mechanism of mast cells in tumor microenvironment.American journal of cancer research · 2024Review
- Mathematical analysis for spatial distribution of vessels, mast cells and adipocytes in superficial fascia.Frontiers in physiology · 2022Article
- Role of Mast Cells in Shaping the Tumor Microenvironment.Clinical reviews in allergy & immunology · 2020Review
- Overcoming randomness does not rule out the importance of inherent randomness for functionality.Journal of biosciences · 2019Review
- Mast cell chymase: morphofunctional characteristics.Histochemistry and cell biology · 2019Review
- Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer.International journal of molecular sciences · 2019Review
- Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway.Journal for immunotherapy of cancer · 2019Article
- Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression.Cell death & disease · 2018Article
- Quantitative Analysis of Immune Infiltrates in Primary Melanoma.Cancer immunology research · 2018Article
- Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.Circulation research · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spatial distribution of mast cells inside the tumor stroma has been little investigated. In this study, we have evaluated tumor mast cells (MCs) distribution in gastric cancer through the analysis of the morphological features of the spatial patterns generated by these cells, including size, shape, and architecture of the cell pattern. The pattern of distribution of tryptase- and chymase-positive MCs around the blood vessels and gastric glands in human gastric adenocarcinoma samples was investigated by immunohistochemical techniques and by introducing a quantitative approach to characterize the spatial distribution of MCs. In human gastric cancer, both chymase-positive MC and vessels exhibited significant deviations from randomness for what it concerns their spatial relationship with gastric parenchyma. As indicated by cell-to-gland distances shorter than expected by chance, in grade II samples a preferential localization of chymase-positive MC near the gastric glands was observed. Interestingly, the same type of spatial association was exhibited by vessels in grade IV samples, where vessel-to-gland distances shorter than expected by chance were observed. These two findings allow to speculate about a sequence of events in which a subpopulation of MC is first recruited around gastric parenchyma to drive the subsequent development of a vascular support to the tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.