ArticleNeurology(R) neuroimmunology & neuroinflammation2017
Validity of a PCR assay in CSF for the diagnosis of neurocysticercosis.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- PCR-Confirmed Convexity Subarachnoid Neurocysticercosis with Negative Serology: A Case Report.Pathogens (Basel, Switzerland) · 2026Article
- Molecular prevalence ofFrontiers in veterinary science · 2025Article
- Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections.Clinical microbiology reviews · 2024Review
- Neurocysticercosis Diagnosis in a Non-Endemic Country: France.Pathogens (Basel, Switzerland) · 2023Article
- Next-generation sequencing combined with serological tests based pathogen analysis for a neurocysticercosis patient with a 20-year history:a case report.BMC neurology · 2021Article
- Subarachnoid neurocysticercosis: emerging concepts and treatment.Current opinion in infectious diseases · 2020Review
- Neurocysticercosis Diagnosed byCase reports in infectious diseases · 2020Article
- Comparison of complementary diagnostic tests in cerebrospinal fluid and serum for neurocysticercosis.Heliyon · 2018Article
- Next generation sequencing based pathogen analysis in a patient with neurocysticercosis: a case report.BMC infectious diseases · 2018Article
- Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Neurocysticercosis.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo prospectively evaluate the validity of a PCR assay in CSF for the diagnosis of neurocysticercosis (NC).
methodsWe conducted a multicenter, prospective case-control study, recruiting participants from 5 hospitals in Cuenca, Ecuador, from January 2015 to February 2016. Cases fulfilled validated diagnostic criteria for NC. For each case, a neurosurgical patient who did not fulfill the diagnostic criteria for NC was selected as a control. CT and MRI, as well as a CSF sample, were collected from both cases and controls. The diagnostic criteria to identify cases were used as a reference standard.
resultsOverall, 36 case and 36 control participants were enrolled. PCR had a sensitivity of 72.2% (95% confidence interval [CI] 54.8%-85.8%) and a specificity of 100.0% (95% CI 90.3%-100.0%). For parenchymal NC, PCR had a sensitivity of 42.9% (95% CI 17.7%-71.1%), and for extraparenchymal NC, PCR had a sensitivity of 90.9% (95% CI 70.8%-98.9%).
conclusionsThis study demonstrated the usefulness of this PCR assay in CSF for the diagnosis of NC. PCR may be particularly helpful for diagnosing extraparenchymal NC when neuroimaging techniques have failed. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that CSF PCR can accurately identify patients with extraparenchymal NC.
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Registered trials
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